# Study of Latinos Investigation of Neurocognitive Aging 2

> **NIH NIH R56** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2020 · $3,641,633

## Abstract

By 2060, the CDC projects that the Latino population will experience the largest increase in Alzheimer's
disease and related dementia (ADRD) cases of all US ethnic/racial groups. The main, if not only, explanation
oft echoed for disparately high Latino ADRD is attributed to early and excess cardiovascular disease (CVD)
morbidity contributing to disparately high ADRD. CVD risk factors emerge earlier among Latinos in midlife,
thereby increasing deleterious exposures to exquisitely sensitive and highly vascularized brain tissue. Yet, to-
date there has not been any study of Latinos with sufficiently deep CVD phenotyping and genotyping to
adequately address this significant public health question. This scientific knowledge gap is a significant
impediment to the field and public health given continued and rapid Latino population growth projections,
particularly for older adults. Latinos now represent nearly one-fifth of the US and 40% of its two most populous
states, California and Texas. In coming decades, the older Latino population (>65 years) will quadruple (391%)
and US public health is ill-prepared for forthcoming demographic and health-related shifts in the population.
The Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA) is the only large, representative and
ongoing longitudinal study of CVD, genomics and cognitive aging and ADRD in diverse Latinos. In this SOL-
INCA renewal, we will leverage 10-years of deep CVD phenotyping, multi-layered -omics and rich sociocultural
data to fill these neglected scientific gaps in our current understanding of ADRD in diverse Latinos.

## Key facts

- **NIH application ID:** 10122035
- **Project number:** 2R56AG048642-06A1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** JAMES B BREWER
- **Activity code:** R56 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $3,641,633
- **Award type:** 2
- **Project period:** 2015-09-01 → 2022-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10122035

## Citation

> US National Institutes of Health, RePORTER application 10122035, Study of Latinos Investigation of Neurocognitive Aging 2 (2R56AG048642-06A1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10122035. Licensed CC0.

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