# Dartmouth Cystic Fibrosis Training Program

> **NIH NIH T32** · DARTMOUTH COLLEGE · 2021 · $198,927

## Abstract

In this application, we propose the Dartmouth Cystic Fibrosis Training Program (DCFTP) to train the next
generation of researchers studying the biology and sequelae of cystic fibrosis (CF). Support is sought for a
comprehensive, highly interactive, interdepartmental training program, with an emphasis on CF
transmembrane conductance regulator (CFTR) trafficking and host-pathogen interactions in the context of
CF. During the 5 year period of the requested support, we anticipate 12 post-qualifying exam, predoctoral
students receiving a maximum of 2 years of training support. Our program has pooled the talents of
dedicated investigators from a wide range of departments (our current program includes faculty in the
departments of Biochemistry, Chemistry, Genetics, Medicine, Microbiology/Immunology, Epidemiology,
Pediatrics, and Engineering) to provide instruction in CF-related research to PhD and MD/PhD students. In
this submission, we propose to directly support four predoctoral fellows. The recently re-named Dartmouth
Cystic Fibrosis Training Program will function in the context of a Research Base already rich in basic,
translational, and clinical CF-related studies. The CF research program at Dartmouth has grown from three
investigators and one NIH grant in 1997 to a community of world-class scientists that currently secures
$69.9M in aggregate total (direct plus indirect) costs of research funding. Our program has 14 participating
Training Faculty working in a range of disciplines, with CF research as the central focus; all Training Faculty
conduct research, are well funded, and teach and mentor our Trainees. This group of basic- and physician-
scientist researchers is actively engaged in CF-related research, with expertise in cell biology, structural
biology, microbiology, immunology, genetics, bioinformatics, statistics, computational biology and
proteomics. As part of developing this program, two new courses and a summer bioinformatics workshop
have been developed by Training Faculty, a new Journal Club has been instituted, a joint interactive group
meeting has been established, and the yearly retreat has been expanded to include academic and
pharma/biotech scientists from across the Northeast, the US and the world. Training-grant funds and
DCFTP-sponsored, Trainee-specific enhanced activities provide a unifying base that greatly facilitates the
strikingly interactive nature of this group (evidenced by 24 collaborative publications in the last 5 years
among our Training and Affiliated faculty) and the collaborative grants held by these faculty. This Program
builds on the historical strengths of the investigators at Dartmouth studying CF.

## Key facts

- **NIH application ID:** 10122977
- **Project number:** 5T32HL134598-05
- **Recipient organization:** DARTMOUTH COLLEGE
- **Principal Investigator:** George A. O'Toole
- **Activity code:** T32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $198,927
- **Award type:** 5
- **Project period:** 2017-03-01 → 2023-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10122977

## Citation

> US National Institutes of Health, RePORTER application 10122977, Dartmouth Cystic Fibrosis Training Program (5T32HL134598-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10122977. Licensed CC0.

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