# Translational Neurophysiology Core

> **NIH NIH P50** · UNIVERSITY OF MINNESOTA · 2021 · $518,429

## Abstract

PROJECT SUMMARY: TRANSLATIONAL NEUROPHYSIOLOGY CORE
The purpose of the Translational Neurophysiology Core is to link the individual Projects by facilitating cross-
species, cross-method behavioral and neural data collection and analysis. Our Center relies on standardized
EEG/fMRI acquisition and processing, as well as consistent DPX and Bandit task data collection with human
control subjects and participants with early psychosis (PROJECTS 3 and 4). In addition, ensemble
recordings and local field potential data, along with DPX and Bandit task behavioral data, will be collected in
nonhuman primates (PROJECT 1) and mice (PROJECT 2). The cross-modal aspect of neural recordings
and behavioral data acquisition presents unique challenges, which will be addressed through three Service
Aims.
Service Aim 1: Support for behavioral data acquisition. Our Center will collect trial-by-trial data in
humans from identical experimental behavioral paradigms (the DPX and Bandit tasks) acquired across both
clinical and normative human samples, studied in multiple settings (e.g. PROJECTS 3 & 4). It is important
that these paradigms be developed to be administered in a highly reliable manner using portable digital
methods, and that the data collected from these paradigms be stored, processed, integrated, and visualized
in a secure, reliable, and accessible manner so that findings can be compared across Projects.
Service Aim 2: Standardized collection, preprocessing, and analysis of simultaneously acquired EEG
and fMRI data in humans. Our goal is to ensure that these data are collected, preprocessed, and analyzed
in an identical manner across PROJECTS 3 and 4, with a focus on acquiring measures that can be used by
the COMPUTATIONAL CORE to assess activity timing, excitatory-inhibitory balance, and system noise.
Service Aim 3: Cross-species neuroanatomical translation. We will facilitate translation of neural circuits
across species by using connectivity data (combination of diffusion MRI and tract- tracing) to identify
homologies across nonhuman primates (PROJECT 1), mice (PROJECT 2), and humans (PROJECTS 3 & 4).

## Key facts

- **NIH application ID:** 10123009
- **Project number:** 5P50MH119569-02
- **Recipient organization:** UNIVERSITY OF MINNESOTA
- **Principal Investigator:** Sarah Rachel Heilbronner
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $518,429
- **Award type:** 5
- **Project period:** 2020-04-01 → 2025-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10123009

## Citation

> US National Institutes of Health, RePORTER application 10123009, Translational Neurophysiology Core (5P50MH119569-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10123009. Licensed CC0.

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