# Expanding WNPRC Infrastructure for HIV/AIDS-Related Research

> **NIH NIH C06** · UNIVERSITY OF WISCONSIN-MADISON · 2020 · $2,000,000

## Abstract

Since 2016, the number of HIV/AIDS-related research protocols at the WNPRC has escalated at a particularly
rapid pace as a result of the growth of the programs of core investigators and an increase in collaborative
studies with affiliate investigators nationwide. This rapid increase has placed a strain on the existing WNPRC
infrastructure dedicated to the support of infectious disease studies (e.g., rhesus macaques, rhesus housing
rooms, and rhesus enclosures). Without increasing the amount of SPF rhesus macaques readily available to
WNPRC PIs (Aim 1) and creating additional space dedicated to holding SIV/SHIV infected animals (Aim 2),
currently funded projects may face delays, established PIs will not be able to submit new HIV/AIDS related
proposals, and the recruitment of additional PIs utilizing the SIV/SHIV-infected rhesus macaque as a model of
human infection with HIV will be hindered.
The first aim of the C06 proposal is to acquire additional enclosures to house social breeding groups of rhesus
macaques at one of the WNPRC vivarium. The additional enclosures will allow the WNPRC to increase its
overall SPF rhesus breeding capabilites, to provide breeding animals and their offspring with a more enriched
and appropriate social environment, and to create pens of specific MHC haplotyped animals (e.g., B*08, B*17,
etc.) for selective breeding if necessary all of which will benefit PIs performing HIV/AIDS-related research. The
second aim of the proposal is to renovate underutilized procedure rooms at a second WNPRC facility into
animal rooms dedicated to HIV/AIDS research. The renovation project will create three new animal rooms
(total capacity of 84 animals) adjacent to our new SIV/SHIV animal wing and will equip the rooms with
contemporary enclosures that promote the psychological well-being of the animals while facilitating safe
performance of experimental procedures in SIV/SHIV infected animals.
This proposal is especially responsive to PAR-20-087 as it will result in the expansion of our SPF Rhesus
macaque breeding colony while simultaneously increasing our SIV/SHIV-infected Rhesus housing capacity.

## Key facts

- **NIH application ID:** 10123447
- **Project number:** 1C06OD030078-01
- **Recipient organization:** UNIVERSITY OF WISCONSIN-MADISON
- **Principal Investigator:** Saverio Vincent Capuano
- **Activity code:** C06 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $2,000,000
- **Award type:** 1
- **Project period:** 2020-09-16 → 2024-09-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10123447

## Citation

> US National Institutes of Health, RePORTER application 10123447, Expanding WNPRC Infrastructure for HIV/AIDS-Related Research (1C06OD030078-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10123447. Licensed CC0.

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