# Administrative Supplement Role of Gut Microbial Dysbiosis in Aging on HIV-associated in the Development of Alzheimer's DiseaseAssociated Dementia (ADRD).

> **NIH NIH U01** · UNIVERSITY OF LOUISVILLE · 2020 · $347,300

## Abstract

The goal of the active U01 is to examine the interactive effects of heavy alcohol use and HIV-1
infection at the level of gut dysbiosis and permeability, ensuing local and systemic inflammation and
its pathogenic role in driving HIV infection and aging-associated neuroinflammation and cognitive
dysfunction. This is being accomplished through longitudinal studies that systematically examine the role of
alcohol use and HIV-1 infection altered microbiome on HIV pathogenesis and development of neurocognitive
dysfunction using 16S rRNA gene sequencing and Whole Genome Shotgun (WGS) metagenomic sequencing
analysis. The supplement is within the scope of the active award and extends the parent study by
including an additional category of participants relevant to Alzheimer’s disease related dementia
(ADRD).
 Specifically, the proposed work is focused on amnestic mild cognitive impairment (aMCI), an early
stage of ADRD. Accordingly, the study will include HIV-infected adults with heavy alcohol use and
aMCI. There is supporting evidence from pre-clinical rodent studies and few human studies for the role of gut
microbiota and peripheral inflammation in the development or progression of Alzheimer’s disease (AD).
Notably, there is a complete lack of comprehensive analysis and characterization of the gut microbial dysbiosis
in heavy alcohol using HIV+ individuals with ADRD. By contrasting neurocognitive, neuroimaging, and
biospecimen indices between heavy alcohol using HIV+ individuals with aMCI and heavy alcohol using HIV+
individuals without aMCI, we will determine whether microbiome abnormalities contribute to the more severe
cognitive disturbances and possible development of ADRD. This will enable us to examine the effects of HIV
and heavy alcohol use in individuals with and without aMCI/ADRD. Based on the one-year scope and
budgetary limits, this supplemental study will differ from the parent project with respect to the inclusion of aMCI
and only a single baseline assessment. These supplemental studies will leverage participant recruitment,
validated clinical and demographic data, biospecimen/biomarker collection, and clinical expertise utilize from
our ongoing NIH sponsored longitudinal studies at the Universities of Louisville (UofL) and Florida (UF) with the
following specific aim: Determine HIV-1 infection- and heavy alcohol use-associated qualitative and
quantitative changes in the gut microbiome (dysbiosis) and attendant intestinal permeability, microbial
translocation (MT) and peripheral inflammation in adults with Alzheimer’s disease related dementias
(ADRD).

## Key facts

- **NIH application ID:** 10123557
- **Project number:** 3U01AA026225-04S1
- **Recipient organization:** UNIVERSITY OF LOUISVILLE
- **Principal Investigator:** SHIRISH S BARVE
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $347,300
- **Award type:** 3
- **Project period:** 2017-09-22 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10123557

## Citation

> US National Institutes of Health, RePORTER application 10123557, Administrative Supplement Role of Gut Microbial Dysbiosis in Aging on HIV-associated in the Development of Alzheimer's DiseaseAssociated Dementia (ADRD). (3U01AA026225-04S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10123557. Licensed CC0.

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