The Center for Clinical and Translational Science and Training (CCTST) aims to maximize the impact of clinical and translational research, in order to improve individual and population health in the Greater Cincinnati area and across the U.S. The CCTST is a collaboration between the University of Cincinnati (UC), two affiliate health care institutions [UC Health and Cincinnati Children’s Hospital Medical Center (CCHMC)], and the broader community – from the local metropolitan area to the CTSA network and academic health centers around the country. Under CCTST 3.0, the overall governance structure will remain largely intact, as we continue to benefit from the exceptional leadership team and strong institutional support drawn from our affiliate institutions. Our robust membership base includes over 4,300 investigators, trainees, and staff from the CCTST affiliate institutions, and we have assembled a number of councils and committees with advisory, informational, and stakeholder enfranchisement functions. Through our CCTST Executive Committee, we have brought together and empowered a diverse leadership team that will work to collectively achieve the following overarching aims: Aim 1: Engage stakeholders to collaboratively translate research into improved health care practice and community wellness across the lifespan, using learning health system principles; Aim 2: Develop a diverse, multidisciplinary workforce to conduct innovative, team-based, community-engaged translational research and to disseminate and implement findings to improve health outcomes and reduce disparities; and Aim 3: Optimize the use of biomedical data across the translational research continuum using innovative data science methods to advance discovery, dissemination, and implementation. Our leadership team will optimize collaboration across our core functional areas, with our advisory groups, with our affiliate institutions, and throughout the community. They will also carry out a thorough evaluation program to ensure continuous improvement and maximum impact of our services, centered around assessment of impact, return on investment, and value. Under CCTST 3.0, we will continue to maximize quality and efficiency by harmonizing all services such that the needs of each investigator are met to the limits of our mission, resources, and abilities.