The Center for Clinical and Translational Science and Training (CCTST) must have adequate support of diverse network-wide activities to facilitate success in clinical and translational research. Our last competing renewal contained a Network Resources section for the first time, as well as Optional Functions. With regard to Optional Functions, we submitted: 1) Acute Care Research; and 2) Lifespan Data Integration. For Network Resources and Multi-Site Study Support, we focused on local investigator support for multi-site trials via our two Clinical Trial Offices (CTOs), since the Trial Innovation Network (TIN) had not yet been formed. In this competing renewal, CCTST 3.0, we continue to support local multi-site investigators in the same fashion, with some significant changes underway to improve CTO services across the Academic Health Center (AHC). In addition, we have a fully functional TIN Hub Liaison Team and have had increasing collaboration with the TIN. We now have two local investigators receiving TIN services and are continuing toward our participation in TIN trials. We intend to further increase AHC-wide collaboration in support of multi-site human subjects research. We have operationalized the Acute Care Research Core as a permanent feature of the CCTST. This builds on the success of the Acute Care Research optional function to date, leverages our many unique strengths in acute care research, and highlights the importance of acute care research within our AHC. We will adopt the guiding principles of Learning Health Systems applied to continuous improvement of our Network Resources described herein, along with close collaboration with the other CCTST cores. We will 1) engage stakeholders in meaningful multi-site clinical research, including further involvement in TIN studies; 2) continue to develop a multidisciplinary workforce with expertise in multi-site research, especially acute care research; and 3) optimize the use of biomedical data in support of all aspects of clinical research locally and nationally.