# Multiomic Signatures of Microbial Metabolites Following Prebiotic Fiber Supplementation Alzheimer's supplement

> **NIH NIH R01** · STANFORD UNIVERSITY · 2020 · $394,250

## Abstract

ABSTRACT
Phenolic-rich prebiotic fiber has been correlated with a number of positive health outcomes, despite low
bioavailability. A large portion of the gut microbiota metabolize these fibers releasing a range of phenolic acids,
which are believed to be salient bioactive components driving reduction in disease risk. Despite this, little
evidence exists linking specific gut bacteria with the metabolites they produce and the downstream biological
effects that these compounds exert. We therefore propose to assemble a cohort of individuals that will receive
prebiotic supplementation during comprehensive, longitudinal characterization of the microbiota and host
changes with multiple omics assays (Aim 1). We will then integrate these multiomic data (Aim 2), generating
unique biological signatures that define the role microbial metabolites from specific bacteria play in host
biological activity. To find associations between multiomic systems biology, fiber supplementation, and
cognition we propose to add cognitive tests to out longitudinal study. Through this study we expect to gain a
detailed and clear understanding of the physiological changes that occur in the microbiome and host in response
to dietary supplementation with prebiotic fiber.

## Key facts

- **NIH application ID:** 10123770
- **Project number:** 3R01AT010232-03S1
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** MICHAEL P. SNYDER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $394,250
- **Award type:** 3
- **Project period:** 2018-09-20 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10123770

## Citation

> US National Institutes of Health, RePORTER application 10123770, Multiomic Signatures of Microbial Metabolites Following Prebiotic Fiber Supplementation Alzheimer's supplement (3R01AT010232-03S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10123770. Licensed CC0.

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