# ONPRC PENS Expansion

> **NIH NIH C06** · OREGON HEALTH & SCIENCE UNIVERSITY · 2020 · $2,000,000

## Abstract

PROJECT SUMMARY
The goal of this proposal is to continue to support US Public Health Service (PHS)-sponsored HIV/AIDS
research programs to serve the needs of internal and external investigators by expanding nonhuman primate
(NHP) indoor-outdoor breeding space for high-priority NHP HIV/AIDS research studies utilizing simian
immunodeficiency virus (SIV) and chimeric simian-human immunodeficiency virus (SHIV).
The proposed new Primate Enclosures in a Natural Setting (PENS) crib-style animal shelter will comprise a
total of 5,574 gross square feet (GSF) including (12) interior and (12) connected exterior animal runs as well as
an interior central service breezeway to expand the capacity of animal holding and breeding areas on campus.
Each of the (12) PENS units will adjoin a covered central breezeway for animal care and service access. The
breezeway will have alcoves between pairs of units that will provide safe access and workspace clearances to
the critical infrastructure for the building. Each interior pen will have a single personnel door for staff access as
well as a vertical sliding animal door for movement of nonhuman primates during cleaning.
The new PENS units are intended to be functionally and aesthetically similar to the existing adjacent PENS
Crib Shelter, a previous NIH grant-funded project completed in 2011. That project included a Central Services
building that will provide utilities infrastructure (high temperature/pressure wash-down water, low-voltage
systems and power) to the proposed new PENS expansion shelter. Exterior circulation, landscaping and civil
design will accommodate ease of access for personnel and equipment as necessary and serviceability of
mechanical, electrical and plumbing utilities between the shelter and the service building.
This project builds upon the earlier design and implementation of PENS at the ONPRC and success in
demonstrating the utility of this design for breeding of SPF4 rhesus macaques for HIV/AIDS research. The
resulting building will increase harem-style breeding facilities designed for small breeding groups assure
knowledge of paternity and MHC Class I alleles, and will allow socialization of animals in matriarchal groups
from birth to assignment. Failure to expand the breeding capacity will limit the Center's ability to support the
research programs of our current and recently recruited NHP/AIDS core investigators. Further, it will
compromise the ONPRC's ability to accomplish its mission as a national scientific resource for animals,
expertise, and specialized facilities and equipment to scientists conducting infectious disease research in
NHPs.

## Key facts

- **NIH application ID:** 10123820
- **Project number:** 1C06OD030082-01
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** Nancy L Haigwood
- **Activity code:** C06 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $2,000,000
- **Award type:** 1
- **Project period:** 2020-09-18 → 2023-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10123820

## Citation

> US National Institutes of Health, RePORTER application 10123820, ONPRC PENS Expansion (1C06OD030082-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10123820. Licensed CC0.

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