# Alliance Alzheimers Disease Model Portal

> **NIH NIH U24** · CALIFORNIA INSTITUTE OF TECHNOLOGY · 2020 · $404,470

## Abstract

Summary/Abstract
This project will make the model organism data and curation in the Alliance of Genome Resources – which
harmonizes and integrates information from mouse, rat, zebrafish, Drosophila, C. elegans and budding yeast –
readily available for Alzheimer's Disease (AD) researchers. This information notably includes gene function,
interaction with AD associated genes; relevant models of disease, gene function and variant effect. The entire
user experience – from home page, to search, to gene and variant pages, as well as the information in each
display widget and analysis tools – will be tailored to the AD researcher. The Alliance now has about 3000 genes
from six species that have annotations to AD, but this is embedded in over 120,000 genes in the Alliance purview,
and thus prioritization will save time and attention, providing up to a 40-fold enrichment of information. To support
an AD specific web portal, algorithms will be developed and deployed that prioritize, based on AD-relevance,
information to be displayed and search results. Search of the portal will prioritize AD-relevant entities and terms.
Information and the order of display will prioritize AD researcher interests. Algorithmically-generated summaries
of gene function will focus on AD-relevant information. An AD-focused literature search and text-mining system
will be implemented.

## Key facts

- **NIH application ID:** 10123887
- **Project number:** 3U24HG010859-02S1
- **Recipient organization:** CALIFORNIA INSTITUTE OF TECHNOLOGY
- **Principal Investigator:** CAROL J BULT
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $404,470
- **Award type:** 3
- **Project period:** 2019-09-18 → 2024-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10123887

## Citation

> US National Institutes of Health, RePORTER application 10123887, Alliance Alzheimers Disease Model Portal (3U24HG010859-02S1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10123887. Licensed CC0.

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