# Predictors of Influenza-Associated Absenteeism and Impact of Vaccination in a Cohort of Guatemalan Agricultural Workers

> **NIH NIH K23** · UNIVERSITY OF COLORADO DENVER · 2020 · $49,756

## Abstract

PROJECT SUMMARY/ABSTRACT
This is an Administrative Supplement Application to carry out SARS-CoV-2 PCR testing in an existing NIAID-
funded study (1K23AI143967) evaluating the clinical and economic impacts of influenza in Guatemalan
agricultural workers. The Parent Study includes the enrollment of an existing cohort (n=2,706) of Guatemalan
agricultural workers with high rates of chronic medical conditions (CMCs) into a prospective active surveillance
system for cough and fever (severe acute respiratory illness [SARI]). Workers meeting the case definition are
tested for influenza A/B and RSV (Roche cobas® Liat RT-PCR Assay) and then clinical and economic
outcomes are assessed using follow up surveys and company reported absenteeism and productivity data.
 This Administrative Supplement will allow us to maintain our cough/fever surveillance system, given an
increase in expected cases due to SARS-CoV-2, and to perform RT-PCR testing for SARS-CoV-2. We
hypothesize that, similar to influenza, COVID-19 will place a significant clinical and economic burden on
agricultural workers, especially the large proportion with CMCs, such as chronic kidney disease of unknown
origin (CKDu, aka “Mesoamerican nephropathy”), given existing data showing a significantly increased risk of
severe disease. Evaluating these outcomes in an existing prospective cohort will allow us to measure these
burdens on a population-level, which will provide critical data in understanding the true impact of disease. We
aim to implement our SARS-CoV-2 testing immediately, analyze and disseminate our results quickly, and
make samples from our specimen biobank (annual blood and urine, acute illness respiratory and blood)
available for additional research.

## Key facts

- **NIH application ID:** 10124496
- **Project number:** 3K23AI143967-01S1
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** Daniel Olson
- **Activity code:** K23 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $49,756
- **Award type:** 3
- **Project period:** 2020-05-20 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10124496

## Citation

> US National Institutes of Health, RePORTER application 10124496, Predictors of Influenza-Associated Absenteeism and Impact of Vaccination in a Cohort of Guatemalan Agricultural Workers (3K23AI143967-01S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10124496. Licensed CC0.

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