# Improvement of Preclinical Oxygen Imager JIVA-25

> **NIH NIH R44** · O2M TECHNOLOGIES, LLC · 2020 · $255,150

## Abstract

Abstract
JIVA-25 is a small footprint 25 mT preclinical oxygen imager based on the principles of electron paramagnetic
resonance oxygen imaging. JIVA-25 can provide oxygen maps in tissues with 1 mm spatial resolution, 1 torr
oxygen resolution, and 1-10 min temporal resolution. No other competing method can provide accurate
noninvasive pO2 maps with such precision. In tumors, accurate real-time pO2 maps will lead to a better
understanding of hypoxia linked to the success of cancer treatment and will eventually result in oxygen guided
cancer therapies in clinics. The oxygen guided radiation therapy is expected to reduce the delivered high
radiation dose-volume by lowering the dose to well-oxygenated tumor tissues that will reduce the radiation
side effects. The absence of preclinical (animal) oxygen imaging data is the major impediment in the
development of evidence base translation of complex oxygenation-based cancer therapies into clinics.
Providing the research community with the JIVA-25 instrument is the first step in achieving these goals.
This proposal is designed to improve the form factor, manufacturability, and user-friendliness of the
instrument. Our goal is to achieve a professional instrument with the help of a professional design firm that
will keep the main features of the instrument intact but help with improved design of various components,
such as a resonator, magnet enclosure, instrument rack, and other accessories. This supplement is important in
placing JIVA-25 in the competitive preclinical imaging market.

## Key facts

- **NIH application ID:** 10124582
- **Project number:** 3R44CA224840-03S1
- **Recipient organization:** O2M TECHNOLOGIES, LLC
- **Principal Investigator:** Mrignayani Kotecha
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $255,150
- **Award type:** 3
- **Project period:** 2019-07-08 → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10124582

## Citation

> US National Institutes of Health, RePORTER application 10124582, Improvement of Preclinical Oxygen Imager JIVA-25 (3R44CA224840-03S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10124582. Licensed CC0.

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