# TASK AREA B: RSA NO. 231 FOR HUMORAL EVASION BY ADENO-ASSOCIATED VIRAL (AAV) VECTORS FOR DR. ASOKAN

> **NIH NIH N01** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2020 · $218,836

## Abstract

Pre-existing immunity to recombinant adeno-associated viral (AAV) vectors has been a major hindrance to vector dosing and re-administration, which may be required to ensure the durability and long-term efficacy of gene therapy for some diseases. Eliminating neutralizing antibodies against different AAV serotypes that arise from prior exposure could enable effective gene transfer and avoid the problems inherent with pre-existing antibodies. In this pilot study, the PI proposes to assess the ability of a rapid antibody clearing agent (ACA) (cysteine protease) to diminish pre-existing humoral immunity to AAV capsids and determine if this approach could enable AAV vector administration in young seropositive rhesus monkeys. If successful, the proposed approach could potentially expand patient recruitment in gene therapy clinical trials and also increase the availability of nonhuman primates for preclinical studies.

## Key facts

- **NIH application ID:** 10124656
- **Project number:** 75N92019D00040-0-759202000001-1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** Alice F Tarantal
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $218,836
- **Award type:** —
- **Project period:** 2020-02-03 → 2020-10-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10124656

## Citation

> US National Institutes of Health, RePORTER application 10124656, TASK AREA B: RSA NO. 231 FOR HUMORAL EVASION BY ADENO-ASSOCIATED VIRAL (AAV) VECTORS FOR DR. ASOKAN (75N92019D00040-0-759202000001-1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10124656. Licensed CC0.

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