# SCIENTIFIC FEASIBILITY OF HIGH FLUORIDE-POVIDONE IODINE TOOTHPASTE

> **NIH NIH R43** · ADP SILVER DENTAL ARREST, LLC · 2021 · $178,410

## Abstract

ABSTRACT
 This SBIR Phase I proposal requests $178,410.00 (total cost) support for Advantage Silver Dental
Arrest, LLC. to develop and assess the technical and scientific feasibility of High Fluoride Toothpaste that also
contains Povidone Iodine as a commercial product to arrest dental caries. This proposal responds to the
NIDCR Preclinical Research topic: “Preclinical research and development activities for dental and craniofacial
technologies (including devices, diagnostic instruments, reconstructive materials, pharmaceuticals,
therapeutics, vaccines, and biologics) that require review and approval by the FDA as a regulated product
before commercial distribution”.
 The aims: 1) To develop a fluoride toothpaste that also contains PVP-I, assure stability, and
demonstrate release of fluoride and iodine from its matrix; 2) To assess antibacterial activity of newly
formulated toothpaste that contains both fluoride and PVP-I against caries causing bacteria, and to assess
whether these agents act in synergistic, merely additive, or antagonistic fashion; and 3) To assess whether
formulations of the toothpaste shown by the work of aim 2 persist in both inhibition of de-mineralization of
enamel and also persist in fostering re-mineralization of enamel.
 The high fluoride antimicrobial toothpaste envisioned by Advantage Silver Dental Arrest, LLC builds on
the currently available prescription high fluoride toothpastes but for which the available evidence of effectiveness
is limited, yet their use appears to be growing. Researchers for some time have suggested that combining topical
antiseptics to control tooth surface colonization by cariogenic bacteria with fluoride that primarily remineralizes
enamel has promise. The new prescription toothpaste will be inexpensive, easy to use, and well tolerated by
patients of all ages and special needs.
 This effort brings partners with a strong record in materials physics, microbiology, caries research and
public health together with oral care industry partners who have a history of successfully bringing products to
market. The size of the United States topical fluoride market is estimated to total $185 - $205 million annually.
We conservatively expect to capture between 5% and 10% of the U.S market 3 years post FDA approval.
Key words: dental caries; sodium fluoride; povidone-iodine; toothpaste

## Key facts

- **NIH application ID:** 10124733
- **Project number:** 1R43DE030303-01
- **Recipient organization:** ADP SILVER DENTAL ARREST, LLC
- **Principal Investigator:** Peter M Milgrom
- **Activity code:** R43 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $178,410
- **Award type:** 1
- **Project period:** 2021-02-01 → 2023-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10124733

## Citation

> US National Institutes of Health, RePORTER application 10124733, SCIENTIFIC FEASIBILITY OF HIGH FLUORIDE-POVIDONE IODINE TOOTHPASTE (1R43DE030303-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10124733. Licensed CC0.

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