# Metabolic Control of Brucellosis

> **NIH NIH R21** · UNIVERSITY OF MISSOURI-COLUMBIA · 2021 · $187,839

## Abstract

Abstract:
 Brucella spp can infect almost any organ or organ system in humans and thus Brucella
must adapt to different metabolic conditions encountered in these tissues. However, the local
availability of carbon sources possibly used by Brucella is unclear, if not controversial. Therefore,
determining the metabolic conditions within target organs of Brucella, and how these conditions
are affected by the host immune response, is essential to understand how Brucella is able to
cause multifocal disease. Here we show MyD88 signaling regulates host metabolism, which in
turn alters the metabolic requirements for Brucella virulence. In the proposed studies, we will
investigate the temporal, and tissue-specific role of MyD88 on host metabolism during brucellosis
and determine the effects of MyD88-dependent metabolites on control of infection.

## Key facts

- **NIH application ID:** 10125091
- **Project number:** 5R21AI146397-02
- **Recipient organization:** UNIVERSITY OF MISSOURI-COLUMBIA
- **Principal Investigator:** Jerod Skyberg
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $187,839
- **Award type:** 5
- **Project period:** 2020-03-10 → 2024-02-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10125091

## Citation

> US National Institutes of Health, RePORTER application 10125091, Metabolic Control of Brucellosis (5R21AI146397-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10125091. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*