# Contribution of host genetic factors to intestinal Coxsackievirus replication

> **NIH NIH R03** · INDIANA UNIVERSITY INDIANAPOLIS · 2021 · $114,530

## Abstract

Project Summary
Coxsackievirus is a common infection that causes viral myocarditis, meningoencephalitis, and hand, foot, and
mouth disease in children and adults. Coxsackievirus is spread by the fecal-oral route and initiates infection in
the gastrointestinal tract. There are no therapeutics to Coxsackievirus, in part due to a lack of knowledge in how
Coxsackievirus initiates infection in the intestine. We recently developed a mouse model to investigate
Coxsackievirus B3 (CVB3) replication in the intestine. Using this model, we found that, similar to humans, male
mice succumb to CVB3-induced disease, whereas female mice do not. Intriguingly, CVB3 replication in the
intestine of male mice is enhanced compared to female mice. Recent data indicate that non-hormonal factors,
such as host genes, play a role in intestinal CVB3 replication. Therefore, the goal of this study is to identify host
genes that impact viral replication in the intestine. These studies will shed light on the mechanism of CVB3
replication in the intestine.

## Key facts

- **NIH application ID:** 10125151
- **Project number:** 5R03DK124749-02
- **Recipient organization:** INDIANA UNIVERSITY INDIANAPOLIS
- **Principal Investigator:** Christopher Michael Robinson
- **Activity code:** R03 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $114,530
- **Award type:** 5
- **Project period:** 2020-03-10 → 2023-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10125151

## Citation

> US National Institutes of Health, RePORTER application 10125151, Contribution of host genetic factors to intestinal Coxsackievirus replication (5R03DK124749-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10125151. Licensed CC0.

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