# Parasite Genetics Core

> **NIH NIH U19** · JOHNS HOPKINS UNIVERSITY · 2021 · $228,603

## Abstract

Abstract 
The aim of the Parasite Genetics Core (PGC) will be to enable the Southern and Central Africa ICEMR to 
apply state-of-the-art next generation sequencing and bioinformatic tools to better understand malaria 
epidemiology and the impact of control interventions in Zambia, Zimbabwe and the Democratic Republic of the 
Congo (DRC). Specifically, the long term objectives and goals of the PGC are to provide; laboratory analyses 
of parasites from ICEMR samples, bioinformatic processing of next-generation sequencing data for projects in 
this previous aim, training for investigators in this and other ICEMRs, quality control of genetic data and 
samples for analyses conducted at field sites. The PGC will provide a centralized laboratory for genetic 
analysis of parasite samples from all three projects within the ICEMR. These laboratory analyses will focus 
primarily on next generation sequencing techniques: (1) amplicon deep sequencing, (2) pooled amplicon deep 
sequencing and (3) PoolSeq. The proposed laboratory work for the PGC includes activities in: Project A: 
Malaria Control in Southern and Central Africa (Epidemiology), Project B: Intractable Malaria Vector 
Populations and Residual Transmission in Southern and Central Africa (Transmission I), and Project C: 
Achieving, Sustaining, and Documenting Malaria Elimination (Transmission II). Data analysis of next 
generation sequencing is computationally intensive and rapidly developing. Thus, a portion of the core will be 
dedicated to assisting investigators with these state-of-the art analyses. The facilities at the PGC will allow us 
to host investigators from the Southern and Central Africa ICEMR, as well as collaborate with investigators 
from other ICEMRs, in order for the techniques to be transferred to other institutions. This will allow us to 
potentially foster cross ICEMR collaboration and to train non-US based scientists on state of the art population 
genetics laboratory and analysis methods.

## Key facts

- **NIH application ID:** 10127558
- **Project number:** 5U19AI089680-12
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Jonathan J Juliano
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $228,603
- **Award type:** 5
- **Project period:** 2010-07-01 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10127558

## Citation

> US National Institutes of Health, RePORTER application 10127558, Parasite Genetics Core (5U19AI089680-12). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10127558. Licensed CC0.

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