# Project A: Epidemiology

> **NIH NIH U19** · JOHNS HOPKINS UNIVERSITY · 2021 · $23,998

## Abstract

Abstract
Despite progress in reducing malaria morbidity and mortality in much of southern Africa, including Zambia and
Zimbabwe, challenges persist. In some regions, such as Nchelenge District in northern Zambia, malaria
transmission remains high despite implementation of standard case management and vector control
measures. Across the border in the Democratic Republic of Congo, only limited vector control interventions
have been implemented. Further south, in Mutasa District in eastern Zimbabwe, recent gains in malaria control
and elimination are threatened by emerging insecticide resistance and cross-border malaria transmission. The
potential risk of emergent drug resistance is a threat to regional malaria control. Importantly, increased
resources and efforts will be allocated to reduce malaria transmission in high transmission settings such as
Luapula Province in northern Zambia and the adjacent Katanga Province in the Democratic Republic of Congo
(DRC), and to prevent resurgence and eliminate malaria in areas with seasonal transmission such as eastern
Zimbabwe. The Southern and Central Africa ICEMR will address three research questions of critical
importance to malaria control in these epidemiological settings: 1) patterns and drivers of moderate to high
level malaria transmission; 2) specific barriers to control, including insecticide resistance, antimalarial drug
resistance and cross-border malaria transmission; and 3) the optimal combination of malaria control
interventions.

## Key facts

- **NIH application ID:** 10127561
- **Project number:** 5U19AI089680-12
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** WILLIAM J MOSS
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $23,998
- **Award type:** 5
- **Project period:** 2010-07-01 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10127561

## Citation

> US National Institutes of Health, RePORTER application 10127561, Project A: Epidemiology (5U19AI089680-12). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10127561. Licensed CC0.

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