# Project C: Transmission II Elimination

> **NIH NIH U19** · JOHNS HOPKINS UNIVERSITY · 2021 · $48,686

## Abstract

Abstract
Zambia is committed to achieving malaria elimination by 2020. In April 2015, the Zambian National Malaria
Control Centre (NMCC) released a strategic plan titled “Moving from accelerated burden reduction to malaria
elimination: the Zambia 2015–2020 strategy” with the goals of eliminating malaria transmission by 2020 and
preventing reintroduction. These goals are to be achieved through standard interventions such as case
management, long-lasting insecticide-treated nets (LLINs), indoor residual spraying (IRS), surveillance and
behavioral change communication as well as enhanced strategies such as mass drug administration, and will
be supported in part by the President's Malaria Initiative, United States Agency for International Development,
Bill & Melinda Gates Foundation and the Global Fund to Fight AIDS, Tuberculosis and Malaria. Southern
Province has the lowest parasite prevalence in the country and is the province most likely to achieve
elimination first. Consistent with the theme of the Southern and Central Africa ICEMR to address critical
research questions on barriers to malaria control and elimination, specifically explanations for continued
malaria transmission different epidemiological settings despite current public health interventions, we will
investigate barriers to achieving, sustaining and documenting malaria elimination in Southern Province,
Zambia. Our aims address four areas of critical importance to achieving, sustaining and documenting malaria
elimination: 1) surveillance for residual foci of transmission; 2) relative contributions to low-level transmission of
the chronically-infected, asymptomatic reservoir and imported malaria; 3) the role of secondary vectors in
sustaining residual transmission; and 4) the use of serosurveillance to document malaria elimination.

## Key facts

- **NIH application ID:** 10127563
- **Project number:** 5U19AI089680-12
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** WILLIAM J MOSS
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $48,686
- **Award type:** 5
- **Project period:** 2010-07-01 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10127563

## Citation

> US National Institutes of Health, RePORTER application 10127563, Project C: Transmission II Elimination (5U19AI089680-12). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10127563. Licensed CC0.

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