# Intestinal mucosal wound resealing

> **NIH NIH R01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2021 · $460,345

## Abstract

Abstract
The gastrointestinal epithelium plays a central role in maintaining and coordinating mucosal homeostasis and
immunity. Intestinal epithelial barrier compromise in mucosal wounds is seen in many pathologic states that
encompass inflammatory bowel diseases, ischemia, mechanical injury and surgical procedures. Coordinated
epithelial cell migration and proliferation are crucial for mucosal wound closure, yet many aspects of this
complex process are not well understood. Mucosal reparative events are orchestrated by the epithelium itself
as well as by a spatiotemporal interplay of epithelial-immune cell cross-talk. Select inflammatory cytokines
initiate synthesis of mediators that not only serve to influence the inflammatory cascade but also dismantle it
and promote repair. The overarching hypothesis is that temporal recruitment and activation of immune cells
into injured sites influence epithelial signaling to promote repair. Thus, the proposed studies will identify and
characterize mechanisms by which immune cell derived mediators influence and regulate intestinal epithelial
wound repair. Knowledge gained from these studies in the short term will provide a better understanding of
basic mechanisms by which inflammatory cell and epithelial mediators control intestinal epithelial homeostasis
and mucosal wound repair. In the long term these studies will aid in the development of new therapeutic
strategies aimed at promoting intestinal mucosal wound repair.

## Key facts

- **NIH application ID:** 10127623
- **Project number:** 5R01DK055679-22
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** ASMA NUSRAT
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $460,345
- **Award type:** 5
- **Project period:** 1998-08-01 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10127623

## Citation

> US National Institutes of Health, RePORTER application 10127623, Intestinal mucosal wound resealing (5R01DK055679-22). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10127623. Licensed CC0.

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