# MODULATION OF CARDIAC NAV CHANNEL FUNCTION AND ELECTROPHYSIOLOGY BY INTERACTING MOLECULES

> **NIH NIH R01** · WASHINGTON UNIVERSITY · 2021 · $381,250

## Abstract

Abstract
In excitable cells, voltage-gated Na+ channels initiate the action potential. In recent years, it has
been discovered that these channels are composed of many parts to form a macromolecular
signaling complex. These different parts precisely tune the function of Na+ channels to the cells
that they reside in. This proposal aims to begin to discover mechanisms of how one
component, the β-subunits, modulate the function and pharmacology of Na+ channels. If the
proposed aims succeed, this new understanding could provide a route to more effective and
precisely-directed therapies for excitability disorders such as arrhythmia and epilepsy.

## Key facts

- **NIH application ID:** 10127686
- **Project number:** 5R01HL136553-05
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** JONATHAN R SILVA
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $381,250
- **Award type:** 5
- **Project period:** 2017-04-01 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10127686

## Citation

> US National Institutes of Health, RePORTER application 10127686, MODULATION OF CARDIAC NAV CHANNEL FUNCTION AND ELECTROPHYSIOLOGY BY INTERACTING MOLECULES (5R01HL136553-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10127686. Licensed CC0.

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