# Immunological Profiles and prognostic outcomes in patients with alcoholic hepatitis

> **NIH NIH U01** · INDIANA UNIVERSITY INDIANAPOLIS · 2020 · $194,079

## Abstract

Project Summary
This application is in response to Notice of Special Interest: Alzheimer's-focused administrative supplements
for NIH grants that are not focused on Alzheimer's disease NOT-AG-20-008. This proposal is a supplement to
our current 1U01AA026917 study on “Immunological Profiles and prognostic outcomes in patients with
alcoholic hepatitis”. Here, we will extend our observation on alcohol and immune responses into its effect on
cognitive function, notably Alzheimer's disease (AD). Current data suggest an important role of liver
dysfunction in AD pathophysiological characteristics; however, the causality, the mechanism, and the
pathways underlying these observations have not been elucidated. We thus hypothesized that ALD is an
important pathological risk factor for AD due to ALD-associated metabolic alteration. We will address this
knowledge gap and test our hypothesis by carefully examining the model systems of ALD in tgF344-AD (Tg)
mutant rat that recapitulates the development of AD pathology and associated behavioral deficits. We will
determine if the presence of ALD accelerates the AD pathophysiological characteristics. In this aim, WT and
Tg rats will be fed with either ethanol or isocaloric liquid diet. Neurological pathology will be determine at 6 and
12 months. We will also determine if the presence of ALD affects the peripheral clearance of Amyloid β (Aβ)
by employing the rat models as well as human samples (liver and serum) from controls and those with
alcoholic cirrhosis. The success of this supplemental proposal will expand the scope of our existing award that
is not currently focused on AD to allow for future studies on ALD and brain (focusing on AD) axis.

## Key facts

- **NIH application ID:** 10127957
- **Project number:** 3U01AA026917-03S1
- **Recipient organization:** INDIANA UNIVERSITY INDIANAPOLIS
- **Principal Investigator:** Suthat Liangpunsakul
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $194,079
- **Award type:** 3
- **Project period:** 2018-09-22 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10127957

## Citation

> US National Institutes of Health, RePORTER application 10127957, Immunological Profiles and prognostic outcomes in patients with alcoholic hepatitis (3U01AA026917-03S1). Retrieved via AI Analytics 2026-06-14 from https://api.ai-analytics.org/grant/nih/10127957. Licensed CC0.

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