# Clinical, Radiologic and Biochemical Factors Related to Diabetes Development after Acute Pancreatitis

> **NIH NIH U01** · JOHNS HOPKINS UNIVERSITY · 2020 · $286,563

## Abstract

Abstract
Nearly 40% of patients develop diabetes after an initial episode of acute pancreatitis (AP). Various studies have
evaluated risk factors for the development of diabetes but they have shown inconsistent findings, suggesting
methodologic shortcomings. The present proposal consists of three specific aims where we will attempt to
determine the biochemical, radiologic and clinical factors related to the development of diabetes after AP. Aim
1: To identify autoantibodies associated with the progression of type 1 diabetes in patients after AP using a large
human proteome array. Aim 2: To study the role of imaging, more specifically quantitative textural analysis to
predict the development of type 1 diabetes after AP. Aim 3 is to build a machine learning model to predict type
1 diabetes after AP using patient-related risk factors, textural analysis on imaging and autoantibodies involved
in disease progression. Our proposal will help us better understand diabetes after AP. Successful completion
of this study has the potential to improve management for AP.

## Key facts

- **NIH application ID:** 10128083
- **Project number:** 1U01DK127400-01
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** ZHAOLI SUN
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $286,563
- **Award type:** 1
- **Project period:** 2020-09-16 → 2025-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10128083

## Citation

> US National Institutes of Health, RePORTER application 10128083, Clinical, Radiologic and Biochemical Factors Related to Diabetes Development after Acute Pancreatitis (1U01DK127400-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10128083. Licensed CC0.

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