# Epigenetic mechanisms regulating neuron production during cortical development

> **NIH NIH P20** · SANFORD RESEARCH/USD · 2020 · $320,474

## Abstract

The primary goal of this application is to establish a foundation of basic scientists with translational research
projects studying developmental mechanisms underlying children’s disease by establishing the Center for
Pediatric Research. The origin of many pediatric diseases is from altered developmental programming related
to the processes of cell proliferation, morphogenesis, migration, differentiation, and programmed death. These
developmental processes are at the root of pediatric disease and are disrupted through genetic disorders,
aberrant fetal programming, altered growth & development, and environmental pressures. Our multidisciplinary
Center applies genetic, biochemical, cell, and molecular approaches across several model organisms to
characterize alterations during development as they pertain to pediatric diseases and disorders. For phase II
we will continue to build upon the success of phase I efforts to create a critical mass of independently funded
investigators within the Center for Pediatric Research by refining our focus to support and mentor junior
investigators whose research investigates how key regulators of cellular pliancy contribute to the
developmental origin of pediatric disorders. Center success will be achieved through the following Aims: 1)
create a supportive environment for the training and mentorship of scientists studying how regulation of cell
pliancy contributes to pediatric diseases; 2) utilize and enhance existing resources that will enable pediatric
research; 3) expand training and learning opportunities in developmental biology and pediatric disease; and 4)
evaluate success of the Center. Through these Aims, the Center for Pediatric Research will develop a strong
foundation in basic and translational research by fostering a collaborative environment for scientists and
physicians. Strengthened by our institution’s strong commitment to children’s medicine, we propose that the
Center will continue to enhance pediatric research efforts in South Dakota.

## Key facts

- **NIH application ID:** 10128366
- **Project number:** 5P20GM103620-08
- **Recipient organization:** SANFORD RESEARCH/USD
- **Principal Investigator:** Louis-Jan Pilaz
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $320,474
- **Award type:** 5
- **Project period:** 2013-09-01 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10128366

## Citation

> US National Institutes of Health, RePORTER application 10128366, Epigenetic mechanisms regulating neuron production during cortical development (5P20GM103620-08). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10128366. Licensed CC0.

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