# Core B: MPN-RC Tissue Bank

> **NIH NIH P01** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2021 · $500,483

## Abstract

Abstract 
Core B, Tissue Bank provides the infrastructure to transport, receive, process, store, and 
distribute tissue specimens obtained from patients with myeloproliferative neoplasms (MPN) as 
well as patients enrolled on clinical trials (Project 4). These specimens are provided to MPN-RC 
investigators performing translational research for the purpose of developing innovative 
therapies (Projects1-3) and to the Biomarker & Bioinformatics Core D to perform biomarker 
analyses to evaluate the effectiveness of specific therapies to deplete MPN hematopoietic stem 
and progenitor cells (HSC/HPC). Tissues are also available to members of the scientific 
community at large for translational research. Translational research is dependent on the ready 
availability of tissues from a sufficient number of accurately diagnosed patients to generate 
statistically significant data. Because the MPNs are relatively uncommon and their accurate 
diagnosis can be difficult, there has been a paucity of tissue, linked to clinical data, available to 
individual investigators at single institutions. Core B fills this void. With an inventory of more 
than 15000 specimens from more than 1500 individual patients with MPNs, Core B maintains 
one of the world's largest inventories of MPN tissues available for research. In addition, Core B 
collects specimens from patients participating in MPN-RC sponsored clinical trials (Project 4) for 
the purpose of performing biomarker studies to demonstrate the effectiveness of specific 
therapies on the depletion of MPN hematopoietic stem and progenitor cells (HSC/HPC). The 
specific aims of Tissue Bank Core B are to: 1) Receive, process, cryopreserve, and store 
tissues from MPN patients as well as patients enrolled on clinical trials (Project 4) at MPN-RC 
clinical sites; 2) Provide a central repository for MPN tissues that are associated with basic data 
stored in the web-based data bank maintained by Biostatistics and Data Management Core C 
including clinical, and laboratory data that enable selection and distribution of tissues best suited 
for each translational research project; 3) Distribute tissues to: MPN Consortium investigators 
for translational research to develop innovative therapies; MPN Consortium investigators to 
analyze biomarkers to determine therapeutic and pharmacodynamic response to therapy as 
well as to predict disease progression; and scientific community at large for translational 
research. Tissues are available to members of the MPN Research Consortium (MPN-RC) and 
to the scientific community at large for the performance of translational research. Core B is an 
essential shared resource that enables translational research that will ultimately lead to the 
development of molecularly targeted therapies.

## Key facts

- **NIH application ID:** 10128397
- **Project number:** 5P01CA108671-13
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** RONA S WEINBERG
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $500,483
- **Award type:** 5
- **Project period:** 2006-07-01 → 2023-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10128397

## Citation

> US National Institutes of Health, RePORTER application 10128397, Core B: MPN-RC Tissue Bank (5P01CA108671-13). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10128397. Licensed CC0.

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