# Extracorporeal Filtration of Thermosensitive Liposomes

> **NIH NIH R21** · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2021 · $211,076

## Abstract

PROJECT SUMMARY/ABSTRACT
This project will develop a device and perform proof-of-concept studies in a rodent tumor model. The device will
remove the chemotherapy agent Doxorubicin from systemic circulation after targeted delivery to tumors.
Targeted delivery occurs by temperature sensitive liposomes delivering Doxorubicin to tumor regions. By
exposing tumors to hyperthermia (40-42 ºC), drug is locally released and taken up by tumors at high dose.
Following hyperthermia, any remaining drug would result in toxicity to non-targeted tissue, and is removed by
the proposed extracorporeal filter device with real-time quantification of removed drug amount. If successful, this
would represent a novel approach to reduce dose-limiting toxicities, allowing delivery of higher chemotherapy
dose and/or reducing toxicity related side effects.

## Key facts

- **NIH application ID:** 10128707
- **Project number:** 1R21CA249690-01A1
- **Recipient organization:** MEDICAL UNIVERSITY OF SOUTH CAROLINA
- **Principal Investigator:** Dieter Haemmerich
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $211,076
- **Award type:** 1
- **Project period:** 2021-03-01 → 2023-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10128707

## Citation

> US National Institutes of Health, RePORTER application 10128707, Extracorporeal Filtration of Thermosensitive Liposomes (1R21CA249690-01A1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10128707. Licensed CC0.

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