# Data Management and Statistical Core

> **NIH NIH P30** · MASSACHUSETTS GENERAL HOSPITAL · 2021 · $362,534

## Abstract

Massachusetts Alzheimer’s Disease Research Center: Data Core 
The Data Management and Statistics Core (Data Core) of the Massachusetts Alzheimer’s Disease Research 
Center (MADRC) provides state-of-the-art data management and statistical expertise for the MADRC and 
affiliated research studies, for collaborative efforts with other ADRCs, and for national AD/ADRD research 
initiatives. The Data Core is an essential component of the MADRC research enterprise as it facilitates 
scientific rigor, regulatory-compliance and strong connectedness across cores within our Center, and with 
NACC and others outside our Center. It serves to minimize the burdens of research by optimizing study 
efficiencies through subject selection, endpoint selection, facile and adaptive designs, as well as provides 
guidance on rigorous study design and analyses. The Data Core provides informatics expertise and 
assistance, including data-management, timely data transmission to NACC, and query and reporting support to 
all the MADRC Cores. 
We will contribute to MADRC’s goal of understanding heterogeneity through formal statistical modeling and 
use of latent variables, through statistical learning approaches that accommodate longitudinal and survival data 
under biased sampling and through analysis of omics data. We will contribute to MADRC’s goal of 
accelerating toward a cure by developing, importing and disseminating innovative statistical methods and 
informatics tools that will optimize resources. The Core aims to marshal resources (Aims 1,2) to support 
clinical, translational, and basic research in AD/ADRD by contributing statistical and informatics expertise to 
interdisciplinary teams. The Core aims to develop new strategies (Aims 3,4) to provide practical and efficient 
study designs and unbiased analytic methods, and to implement innovative informatics resources. The Core 
aims to build the future (Aims 5,6) by collaborating with the Research Education Component (REC) to train 
clinical and translational researchers in quantitative methods and to attract quantitative scientists to AD/ADRD 
research. 
The Data Core provides guidance on scientific rigor: it assists MADRC researchers with study design and 
ensures valid and accurate analyses of studies across all MADRC Cores. The Data Core also advises MADRC 
researchers on data quality, version control and tracking measures. It ensures all systems are secure and 
within the Partners IT Infrastructure. The Core promotes open and reproducible science by disseminating 
methodological innovations to the scientific community and through data and software sharing.

## Key facts

- **NIH application ID:** 10129263
- **Project number:** 5P30AG062421-03
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** Sudeshna Das
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $362,534
- **Award type:** 5
- **Project period:** 2019-04-15 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10129263

## Citation

> US National Institutes of Health, RePORTER application 10129263, Data Management and Statistical Core (5P30AG062421-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10129263. Licensed CC0.

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