# Core B: Molecular Substrates Core

> **NIH NIH P01** · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2021 · $204,648

## Abstract

PROJECT SUMMARY 
The research described in this program project application employs a broad spectrum of technical approaches 
and requires highly specialized reagents commonly used among the four participating laboratories. The 
Molecular Substrates Core (Core B) is designed to ensure the quality of these reagents and to prevent 
duplicated efforts in setting up specialized preparation procedures. The Core will use streamlined procedures 
and expertise to produce specialized DNA substrates as needed for each Project within the Program. Aim 1 is 
to produce site- and lesion-specific crosslinked DNA and DPC substrates. Aim 2 is to generate functional 
substrates and assay template for in vivo and in vitro studies. Dr. Lei Li will serve as the leader of the Core and 
will directly supervise all the activities. A Coordinator (Research Laboratory) will manage the day-to-day 
operations of the Core, in consultation with the Core leader, based on both short-term and long-term needs of 
each project, and progress will be evaluated in regular team meetings.

## Key facts

- **NIH application ID:** 10129293
- **Project number:** 5P01CA193124-05
- **Recipient organization:** UNIVERSITY OF TX MD ANDERSON CAN CTR
- **Principal Investigator:** Junjie Chen
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $204,648
- **Award type:** 5
- **Project period:** 2020-02-01 → 2023-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10129293

## Citation

> US National Institutes of Health, RePORTER application 10129293, Core B: Molecular Substrates Core (5P01CA193124-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10129293. Licensed CC0.

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