# Clinical Resource Core

> **NIH NIH P30** · UNIVERSITY OF COLORADO DENVER · 2021 · $146,760

## Abstract

CLINICAL RESOURCE CORE
PROGRAM SUMMARY/ABSTRACT
Diabetes represents a worldwide health crisis, with the incidence of both type 1 diabetes (T1D) and type 2
diabetes (T2D) steadily increasing. While autoimmunity is central to T1D, many key aspects of the disease
process are shared by T1D and T2D, including beta cell dysfunction, hyperglycemia, metabolic dysfunction and
insulin resistance. Complications of T1D and T2D also have many similarities, including cardiovascular disease
(CVD) and diabetic kidney disease (DKD), both leading causes of morbidity and mortality. The University of
Colorado Anschutz Medical Center (UC AMC) is among world leaders in clinical translational investigations into
T1D and T2D across the lifespan, as well as in gestational diabetes (GDM) and cystic fibrosis-related diabetes
(CFRD). Funding through the Diabetes Research Center (DRC) would capitalize on these existing
strengths and catalyze the formation of an integrated comprehensive diabetes research program.
The Clinical Resource Core (CR) of the UC Denver DRC stands at the interface of multiple institutions, programs
and individuals, all of whom are working to prevent or ameliorate the devastating long term complications of
diabetes and its high economic burden. The CR core would leverage the current clinical research facilities and
equipment available at the Barbara Davis Center for Childhood Diabetes (BDC), UC AMC’s Clinical Translational
Research Center (CTRC), The University of Colorado Hospital, Denver Veteran’s Administration Medical Center
(VA) and Children’s Hospital Colorado. The DRC CR core would integrate diabetes research across these
institutions through communication and distribution of the resources available, and create shared sample and
data biobanks and a recruiting database of mothers, infants, children, adolescents and adults with diabetes,
diabetes risk and controls. Such integration would accelerate progress and increase the quality of diabetes
research, coalesce existing strengths and strategically focus faculty recruitment in areas of needed
growth. DRC funding would also attract new talent at postgraduate and junior faculty levels and add
unique components of infrastructure needed for discovery.
Specifically, we will improve access and collaborations for recruiting subjects, tracking data and banking tissue
samples from well-phenotyped participants with diabetes and control subjects across the lifespan; establish
collections of samples from our well-characterized subjects and facilitate the ability of DRC users to perform
assays from peripheral blood, serum and plasma utilizing state of the art techniques; improve provision of
specialized diagnostic and analytic services.

## Key facts

- **NIH application ID:** 10129367
- **Project number:** 5P30DK116073-02
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** MARIAN J REWERS
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $146,760
- **Award type:** 5
- **Project period:** 2020-04-01 → 2025-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10129367

## Citation

> US National Institutes of Health, RePORTER application 10129367, Clinical Resource Core (5P30DK116073-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10129367. Licensed CC0.

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