# Research Training in Rheumatology INCLUDE Down Syndrome Supplement

> **NIH NIH T32** · UNIVERSITY OF COLORADO DENVER · 2020 · $85,655

## Abstract

This application for an Administrative Supplement to the “Research Training in Rheumatology” T32 Training
program grant (AR007534: PI- V. Michael Holers) is submitted in response to INCLUDE NOT-OD-20-024,
Availability of Administrative Supplements for the INCLUDE Project. The purpose of this supplement is to
continue support for the professional development of a promising Pediatric Rheumatology trainee, Dr. Jessica
Bloom, in research to advance medical knowledge of autoimmunity in individuals with Down Syndrome (DS).
This T32 program is based at the University of Colorado Anschutz Medical Campus, which is home to one of
the only academic centers fully devoted to DS research - the Linda Crnic Institute for Down Syndrome - as well
as the Anna and John J. Sie Center for Down Syndrome at Children's Hospital Colorado and a thriving
ecosystem of basic and clinical investigators studying DS. Specifically, this supplement will support
investigation to improve the health and well-being of individuals with DS who are affected by idiopathic
pulmonary hemorrhage (IPH) and other acute and chronic hemorrhagic lung disorders. Understanding the
spectrum of disease among individuals with DS will address unmet health needs and inform the medical
community as to the basis for the unique combination of risk and resiliencies of Down Syndrome patients, as
well as improve the health of all individuals. Dr. Jessica Bloom is engaged in a Subspecialists Clinical
Outcomes Research (SCORE) Fellowship in the Adult and Child Consortium for Health Outcomes Research
and Delivery Science (ACCORDS) program at Children's Hospital Colorado. This exceptionally rigorous 2-year
program is designed to train investigators in research methodologies and prepare them for academic careers
in T4 translational research. Dr. Bloom will use this supplement within the SCORE program to test the
hypotheses that chronic hyperactivation of IFN signaling promotes development of IPH in DS patients
and that consensus-based approaches to diagnosis and treatment can improve timely identification
and reduce morbidity and mortality. The Specific Aims of this proposal are 1) to characterize the clinical
spectrum and identify molecular correlates of autoimmunity in DS patients with idiopathic pulmonary
hemorrhage and other acute and chronic hemorrhagic lung disorders; and 2) develop consensus based clinical
care guidelines for the evaluation, management and monitoring of acute and chronic pulmonary hemorrhage in
DS and non-DS patients at Children's Hospital Colorado. The ultimate goals of these studies are to determine
if IPH in individuals with DS is clinically and mechanistically similar to IPH in non-DS patients and to assess the
impact of specific treatment protocols on patient outcomes and promote the development of local and national
collaborative studies. This proposal represents a unique opportunity to bring programs and faculty at UCD
together around investigation and management of autoimmunity in p...

## Key facts

- **NIH application ID:** 10129730
- **Project number:** 3T32AR007534-34S1
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** Vernon Michael Holers
- **Activity code:** T32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $85,655
- **Award type:** 3
- **Project period:** 1986-08-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10129730

## Citation

> US National Institutes of Health, RePORTER application 10129730, Research Training in Rheumatology INCLUDE Down Syndrome Supplement (3T32AR007534-34S1). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10129730. Licensed CC0.

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