# ADNI Psychometrics

> **NIH NIH R01** · UNIVERSITY OF WASHINGTON · 2020 · $147,546

## Abstract

This is a competitive renewal for R01 AG 029672, which applied modern psychometric methods to
neuropsychological data collected by the Alzheimer's Disease Neuroimaging Initiative (ADNI). This competitive
renewal proposes to analyze data from ADNI and from the Australian Imaging, Biomarkers, and Lifestyles of
Ageing (AIBL) study using state-of-the-art psychometric approaches to address substantively important
questions in Alzheimer's disease (AD) research. This project in many ways serves as a bridge between fields
that do not often talk with each other: modern psychometrics and cognitive neuroscience applied to
neurodegenerative conditions. The investigators propose to tackle two important problems in AD research:
improving the ability to detect preclinical disease at the earliest stages (Aim 1) and understanding the clinical
relevance of heterogeneity in the presentation of AD (Aim 2). Advances in modern psychometrics have the
potential to optimize understanding of these critical questions by translating clinical insights into quantitative
analytic approaches. The investigators have a tradition of disseminating their tools to the broader research
community and propose to continue this tradition with a dissemination aim (Aim 3). Support for the next cycle
of funding for this project will ensure continued scientific leadership bridging modern psychometrics and
cognitive neuroscience.

## Key facts

- **NIH application ID:** 10129796
- **Project number:** 3R01AG029672-09S1
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** Paul K Crane
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $147,546
- **Award type:** 3
- **Project period:** 2007-09-15 → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10129796

## Citation

> US National Institutes of Health, RePORTER application 10129796, ADNI Psychometrics (3R01AG029672-09S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10129796. Licensed CC0.

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