# Einstein Mount Sinai Diabetes Research Center

> **NIH NIH P30** · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2021 · $214,034

## Abstract

The Animal Physiology Core (APC) employs sophisticated research methodologies to assist Einstein-Mount 
Sinai Diabetes Research Center (ES-DRC) investigators in the in vivo assessment of glucose and fatty acid 
metabolism, insulin sensitivity and energy homeostasis in mice and rats. Through collaborative efforts with the 
other Cores of the ES-DRC, the APC enables investigators to thoroughly characterize the effects of defined 
pharmacologic, dietary, environmental and genetic alterations on glucose and lipid homeostasis, insulin action, 
and metabolism. To accomplish these goals, the Animal Physiology Core will: 1) Offer advice and instruction to 
students, postdoctoral fellows, investigators and technical staff in the design and performance of physiologic 
approaches and techniques necessary to evaluate the control of glucose homeostasis and insulin action in 
rodents, 2) Make available to investigators specialized measurements of whole body and tissue-specific glucose 
metabolism and insulin action in rodent models including insulin, pancreatic and hyperglycemic clamps and 
spontaneous glucose monitoring, 3) Provide specialized gastrointestinal, neurosurgical and histological models 
for the study of insulin sensitivity, energy balance, and glucose and fatty acid metabolism, including gastric 
bypass and adipose and hepatic tissue denervation, imaging and photo-stimulation, 4) Provide analysis of whole 
body carbohydrate/fatty acid oxidation, energy expenditure, thermogenesis, food intake, and locomotor activity 
using specialized metabolic (indirect calorimetry) rodent cages, 5) Provide assessments of the effects of diet, 
exercise, light/dark cycle and environmental temperature on continuous and acute assessments of glucose 
homeostasis, metabolism, and shivering via electromyography, 6) Make available to investigators specialized 
measurements of rodent adipose tissue distribution using magnetic resonance spectroscopy, microCT, as well 
as measurements of glycogen in liver and muscle, intrahepatic lipids and intramyocellular lipids using nuclear 
magnetic resonance (NMR), 7) Make available to investigators specialized measurements of brain energy and 
glucose utilization by functional magnetic resonance imaging (fMRI) and microPET scanning, 8) Assist 
investigators in the interpretation of data and to design further experimental approaches to reveal the molecular 
and physiological bases of metabolically relevant rodent phenotypes, and 9) Facilitate and integrate the 
functional assessments provided by the APC with assays provided by other ES-DRC Biomedical Cores. All these 
services are available to investigators new to diabetes research, as well as to investigators working on diabetes- 
related projects that can be enriched and extended by the use of the expertise and facilities of this Core.

## Key facts

- **NIH application ID:** 10130494
- **Project number:** 5P30DK020541-46
- **Recipient organization:** ALBERT EINSTEIN COLLEGE OF MEDICINE
- **Principal Investigator:** GARY J SCHWARTZ
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $214,034
- **Award type:** 5
- **Project period:** 2020-04-01 → 2025-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10130494

## Citation

> US National Institutes of Health, RePORTER application 10130494, Einstein Mount Sinai Diabetes Research Center (5P30DK020541-46). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10130494. Licensed CC0.

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