# MACS/WIHS Combined Cohort Study (MWCCS) Administrative Supplement: Association of Alcohol Biomarkers with HIV and Clinical Outcomes

> **NIH NIH U01** · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · 2020 · $18,759

## Abstract

MACS/WIHS Combined Cohort Study (MWCCS) Administrative Supplement:
 Association of Alcohol Biomarkers with HIV and Clinical Outcomes
Abstract. Fund Year 2020 OAR Strategic Funds are requested to perform an objective assessment of
alcohol consumption in the MACS/WIHS Combined Cohort Study (MWCCS) by testing urine and blood
specimens for ethyl glucuronide (EtG) and phosphatidylethanol (PEth), respectively. Specimens will be
collected on existing MACS and WIHS participants who enroll into the MWCCS (n~4000) and in new
MWCCS enrollees (n~1500) during CCS Visits 101 and 102 in order to better characterize alcohol use and
their associations with HIV outcomes (i.e., antiretroviral therapy [ART] adherence, viral suppression
down to a single copy) and clinical outcomes (i.e., liver, cardiac, neurocognitive impairment). This
supplement will support HIV/AIDS research that falls under the following NIH high priority AIDS-
designated topics: 1) HIV-associated comorbidities; and 2) cross-cutting areas including behavioral
sciences, health disparities, and training of the next generation of HIV investigators in substance use and
comorbidities research.

## Key facts

- **NIH application ID:** 10131011
- **Project number:** 3U01HL146245-02S1
- **Recipient organization:** HEKTOEN INSTITUTE FOR MEDICAL RESEARCH
- **Principal Investigator:** Mardge H Cohen
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $18,759
- **Award type:** 3
- **Project period:** 2019-04-01 → 2026-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10131011

## Citation

> US National Institutes of Health, RePORTER application 10131011, MACS/WIHS Combined Cohort Study (MWCCS) Administrative Supplement: Association of Alcohol Biomarkers with HIV and Clinical Outcomes (3U01HL146245-02S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10131011. Licensed CC0.

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