# Core E: Imaging Core

> **NIH NIH P01** · WASHINGTON UNIVERSITY · 2021 · $1,230,321

## Abstract

Core E: Imaging Project Summary
The Imaging Core of the Program Project Grant "Healthy Aging and Senile Dementia" (HASD) will provide
quantitative imaging results for magnetic resonance imaging (MRI), amyloid positron emission tomography
(PET) using [11C]-Pittsburgh Compound B (PiB), and tau PET using [18F]-AV-1451 (T807, flortaucipir) to
support the affiliated Projects and Cores. Quantitative MRI measures will include volumetric MRI, quantitative
and qualitative evaluations of vascular pathology including white matter hyperintensitites (WMH) and cerebral
infarctions and microhemorrhages. Amyloid and tau PET will include summary statistics for standardized
regions and voxelwise z-score analyses for overall burden and change over time. Exploratory measures will
continue to include resting state functional connectivity MRI (rs-fcMRI), diffusion basis spectrum imaging
(DBSI) for neuroinflammation, and arterial spin labelling (ASL) for blood flow using protocols compatible with
the Alzheimer Disease Neuroimaging Initiative (ADNI-3) and the Dominantly Inherited Alzheimer Network
(DIAN). We will continue to explore new MRI and PET options as these become available, such as alternative
PET tracers for tau pathology or synaptic imaging, when relevant to the HASD Projects and Cores. We will
also continue to promote sharing of the HASD imaging data through updated releases of the Open Access
Series of Imaging Studies (OASIS) project.

## Key facts

- **NIH application ID:** 10131742
- **Project number:** 5P01AG003991-38
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** Tammie Lee Smith Benzinger
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,230,321
- **Award type:** 5
- **Project period:** 1997-01-01 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10131742

## Citation

> US National Institutes of Health, RePORTER application 10131742, Core E: Imaging Core (5P01AG003991-38). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10131742. Licensed CC0.

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