# Resource and Service Center

> **NIH NIH U54** · BAYLOR COLLEGE OF MEDICINE · 2020 · $368,747

## Abstract

ABSTRACT
Poor reproducibility of published research employing model organisms and lack of transparency of study designs
have become areas of concern for the scientific community. These issues can profoundly affect the interpretation
of preclinical studies and must be addressed as genome editing technologies permit rapid modeling of patient-
specific, disease-associated genetic variation and translation to the clinic in the forms of patient risk assessment,
management, and treatment. At the heart of reproducibility issues are the model organism themselves. Stability
and identity of the genetic background, genome integrity, and specifics of genetically engineered alleles often
vary between studies due to use of similar but independently developed models or differences in the quality of
model maintenance. Centralization and standardization of high-quality production and maintenance of animal
models can begin to address issues with study reproducibility and transparency and has been highly successful
for our existing animal modeling programs. The Resource and Service Section of the BCM Center for Precision
Medicine Modeling will build on existing expertise and infrastructures of the Undiagnosed Diseases Network
Model Organism Screening Center Drosophila Core at BCM, the BCM Knockout Mouse Production and
Phenotyping site, the BCM-Rice Small Animal Testing Center for the Somatic Cell Genome Editing Program,
and a large rhesus macaque sequence resource in the Human Genome Sequencing Center to (1) acquire,
characterize, and maintain high-quality fly and mouse resources, (2) preserve and distribute fly and mouse
resources, (3) coordinate Center fee-for-service activities for biomedical researchers, (4) communicate the
availability and quality of Center resources and services, and (5) enact procedures to evaluate Section
operations.

## Key facts

- **NIH application ID:** 10132000
- **Project number:** 1U54OD030165-01
- **Recipient organization:** BAYLOR COLLEGE OF MEDICINE
- **Principal Investigator:** John Richard Seavitt
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $368,747
- **Award type:** 1
- **Project period:** 2020-09-15 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10132000

## Citation

> US National Institutes of Health, RePORTER application 10132000, Resource and Service Center (1U54OD030165-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10132000. Licensed CC0.

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