# Administrative Supplement: Biophysical investigations of RNA complexes essential for gene expression

> **NIH NIH R35** · UNIVERSITY OF WISCONSIN-MADISON · 2020 · $47,705

## Abstract

PROJECT SUMMARY/ABSTRACT
The National Magnetic Resonance Facility at Madison (NMRFAM) is a resource center for biomolecular
nuclear magnetic resonance (NMR) spectroscopy. NMRFAM has two missions: 1) to provide affordable access
to established NMR technology and expertise for routine experiments and applications for a wide range of
NMR and other biomedical researchers from across the US, and 2) to expand the frontiers of biomolecular
NMR spectroscopy through resource technology and development programs that span all steps of the NMR
workflow from sample handling and preparation to NMR hardware and pulse sequence development and NMR
data analysis and interpretation. The goal is to make NMR studies more efficient, cheaper, and accessible to
enable broader application of this powerful technology to address pressing biomedical research questions.
NMRFAM strives to be a model to the larger biological community for demonstrating cutting-edge capabilities
of NMR spectroscopy and to provide researchers with resources matched to their particular needs. NMRFAM
provides young investigators and experienced spectroscopists access to state-of-the-art instrumentation with
support for multiple modes of data collection. Facility staff provide expert advice on project design and assist
less experienced NMR users or perform the experiments and data analysis on behalf of collaborators without
NMR experience. NMRFAM develops and disseminates technology and training materials through annual
workshops, one-on-one training, software access in multiple formats, and written and video tutorials. Protocols,
pulse sequences, software tools, and databases developed through NMRFAM’s research activities are made
available to the general scientific community. This administrative supplement will expand the liquid helium
recycling infrastructure at NMRFAM so that all of the liquid helium used in the facility can be recaptured and
recycled to maximize conservation of this non-renewable resource. This will stabilize NMRFAM operations and
hourly rates for instrument use, which is critical given the volatility in the helium market.

## Key facts

- **NIH application ID:** 10132080
- **Project number:** 3R35GM118131-05S1
- **Recipient organization:** UNIVERSITY OF WISCONSIN-MADISON
- **Principal Investigator:** Samuel E Butcher
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $47,705
- **Award type:** 3
- **Project period:** 2016-06-15 → 2021-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10132080

## Citation

> US National Institutes of Health, RePORTER application 10132080, Administrative Supplement: Biophysical investigations of RNA complexes essential for gene expression (3R35GM118131-05S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10132080. Licensed CC0.

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