# Core B -The Bio-Informatics Core

> **NIH NIH P01** · COLUMBIA UNIV NEW YORK MORNINGSIDE · 2021 · $186,032

## Abstract

CORE B SUMMARY
The advent of a wide variety of high throughput techniques has enabled the rapid sequencing of
DNA and RNA and the identification of large numbers of proteins in protein complexes. These
technologies, and their further iterations, have in turn allowed researchers to identify and
catalog the somatic mutations in cancer, associate genetic variants with disease, the
abundance of individual mRNA transcripts in every cell, the nature and expression of a range of
non-coding RNA species, and the nature of modifications on histones and DNA. While the data
arising from these methods has the power to produce enormous insights into cancer, the
datasets produced are large, unwieldy, and of varying quality. Consequently, the role of
bioinformatics in cancer research has become a necessity for the proper interpretation of data.
The goal of Core B is to provide support for program investigators in the analysis and
interpretation of these large datasets. It takes advantage of the expertise of Dr. Levine, a
pioneer in the p53 field who has used computational approaches to reveal new insights into the
p53 network, and the infrastructure at the Institute for Advanced Study. In the current iteration of
the grant, the four projects will interact with Core B to continue to explore the roles and
regulation of p53, with an emphasis on the context dependent nature of p53 action and the
action of p53 mutants, the role of p53 in DNA damage and oncogene responses, the impact of a
novel form of cell death – ferroptosis – on the output of the p53 network, and on developing
therapeutic strategies to exploit p53 mutations or the consequences of p53 loss. All of these
significant questions rely a variety of `omics technologies for assessing gene expression,
chromatin configurations, and many other applications. As such, core B is essential for the
proper analysis of these data and as such is central to the program's success.

## Key facts

- **NIH application ID:** 10132257
- **Project number:** 5P01CA087497-20
- **Recipient organization:** COLUMBIA UNIV NEW YORK MORNINGSIDE
- **Principal Investigator:** Arnold Levine
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $186,032
- **Award type:** 5
- **Project period:** 2000-09-30 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10132257

## Citation

> US National Institutes of Health, RePORTER application 10132257, Core B -The Bio-Informatics Core (5P01CA087497-20). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10132257. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*