# Core D - Immune Monitoring Core

> **NIH NIH U19** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2020 · $246,297

## Abstract

The Human Immune Monitoring Core will characterize phenotypic and functional, ex vivo and in 
vivo signature as well as analyses of innate and adaptive immune responses to DENV infection 
and challenges at various time points whereas information on humoral immune responses to 
DENV will be obtained from the longitudinal studies of infected patients described project 1. 
Together, these validated assays will generate data to be integrated with results from the 
genomic and proteomic cores, and contribute to a DENV signature with clinical value. We 
anticipate that advances in mass spectrometry technologies and sample miniturization 
procedures may increase the sensitivity of global and functional analyses and may reduce the 
amount of sample required for these analyses allowing to extend innate immune competence 
studies to infected and vaccinated patients further refining the identification of a signature 
correlated with clinical status upon DENV infection, vaccine outcome or DC pathogenicity. 
These assays comprise the groundwork for future development of new immune enhancing 
strategies to promote the development of a protective immune response.

## Key facts

- **NIH application ID:** 10132472
- **Project number:** 4U19AI118610-06
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** MIRIAM MERAD
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $246,297
- **Award type:** 4C
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10132472

## Citation

> US National Institutes of Health, RePORTER application 10132472, Core D - Immune Monitoring Core (4U19AI118610-06). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10132472. Licensed CC0.

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