# Core F - Data Management and  Dissemination Core

> **NIH NIH U19** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2020 · $293,018

## Abstract

SUMMARY 
Dengue virus (DENV) induces complex responses in a human host's immune system, modulating entire networks 
of RNA transcription, protein signaling, and metabolism and impacting cellular, tissue, and whole organism 
behaviors. To capture this broad spectrum of changes, DHIPC's Projects 1-3 and Scientific Cores B-D will produce 
a plethora of immune profiling information, including RNA-Seq reads, HLA and KIR typing, proteomics, flow 
cytometry and CyTOF data, cytokine profiling (Luminex) data, neutralizing antibody titers, B/T cell functionality data, 
targeted qRT-PCR levels, and ChIP-Seq/ChIA-PET data. This deluge of data requires rigorous quality control, 
normalization, safeguarding, and organization for ready comparison with public datasets, all of which will be 
performed by this Core, the Data Management and Dissemination Core (Core F). We will then provide this data in 
formats suitable for rapid analysis by Core E (the Data Analysis and Modeling Core), which will integrate them into 
multiscale interaction networks and predictive models capable of producing both mechanistic insights into DENV- 
host interactions and classifiers for clinical outcomes that incorporate an unprecedented amount of training data to 
achieve maximal precision. Finally, this Core will facilitate exploration of these models by interactive visualization 
techniques, including state-of-the-art computer-generated 3D environments and dynamic web dashboards 
accessible to the Individual Projects and Scientific Cores. By “closing the loop” between data produced by the 
Individual Projects, the predictions of Core E's network analysis, and the design of validation studies, our Core will 
serve as DHIPC's engine for truly data-driven, hypothesis-neutral discovery of the subtleties of DENV-host 
interaction that drive significant clinical outcomes.

## Key facts

- **NIH application ID:** 10132474
- **Project number:** 4U19AI118610-06
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** Andrew Kasarskis
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $293,018
- **Award type:** 4C
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10132474

## Citation

> US National Institutes of Health, RePORTER application 10132474, Core F - Data Management and  Dissemination Core (4U19AI118610-06). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10132474. Licensed CC0.

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