# Biostatistics / Bioinformatics Shared Resource

> **NIH NIH P30** · UNIVERSITY OF COLORADO DENVER · 2021 · $280,729

## Abstract

BIOSTATISTICS / BIOINFORMATICS SHARED RESOURCE (Core-667)
ABSTRACT
Overview: The University of Colorado Cancer Center (UCCC) Biostatistics and Bioinformatics Shared
Resource (BBSR) provides biostatistical and bioinformatics leadership and analytic support for laboratory-
based cancer research, experimental therapeutic studies and clinical trials, as well as population-based studies
(e.g., epidemiological, health outcomes and disparities research in our catchment area), to UCCC members.
Expertise: Substantial expertise is available for the analysis of clinical trials, statistical genetics, next-
generation sequencing, predictive modeling, cancer-focused bioinformatics, and health services research.
Services: BBSR support of UCCC members begins with study design to address research questions, along
with sample size determination and analytical plans, as needed for grant and clinical trial development and
protocol submission. BBSR support also includes data and safety monitoring of clinical trials analysis, and
assistance with manuscript preparation in relation to data interpretation and scientific conclusions. The BBSR
actively participates in the Protocol Review and Monitoring System (PRMS) and Data and Safety Monitoring
Committees (DSMC). The BBSR collaborates with other UCCC Shared Resources (particularly Genomics and
the Molecular Pathology Shared Resources) in research studies and the development of new bioinformatic
pipelines. Consultation and Education: Faculty biostatisticians and bioinformaticists also provide educational
opportunities, through one-on-one training in biostatistics and bioinformatics, and are engaged in consultation
with investigators and in the development of novel methods and tools that directly enhance UCCC member
research. Management: The BBSR is comprised of two distinct components – biostatistics and bioinformatics.
Biostatistics is a UCCC Shared Resource while bioinformatics is an institutional core. Both are managed by
UCCC; and both are overseen by the Associate Director for Population Sciences. Use of Services: Since July
2011, 252 investigators have used BBSR services. Sixty-seven percent of users (169) were UCCC members,
representing all 6 Programs and resulting in 112 peer-reviewed publications. CCSG funding represents 25% of
the annual operating budget. The remaining support comes from institutional support (43%), the CCTSI (4%)
and user fees (28%). Future Directions: In the next 5 years, the BBSR will increase bioinformatics staff to
accommodate the predicted growth of research projects that generate high-dimensional data. Future hires in
bioinformatics will leverage resources with the newly-formed Division of Biomedical Informatics and
Personalized Medicine (BIPM). Biostatistics staff hires will also be needed to accommodate planned growth in
Population Sciences and clinical research including trials. Supporting the initiatives that form the Future
Directions in the Director's Overview, the BBSR anticipates ...

## Key facts

- **NIH application ID:** 10133534
- **Project number:** 5P30CA046934-33
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** Dan Theodorescu
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $280,729
- **Award type:** 5
- **Project period:** 1997-04-04 → 2022-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10133534

## Citation

> US National Institutes of Health, RePORTER application 10133534, Biostatistics / Bioinformatics Shared Resource (5P30CA046934-33). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10133534. Licensed CC0.

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