# Pharmacology Shared Resource

> **NIH NIH P30** · UNIVERSITY OF COLORADO DENVER · 2021 · $119,227

## Abstract

PHARMACOLOGY SHARED RESOURCE (Core-529)
ABSTRACT
Overview: An important component of drug-based studies is the assessment of drug exposure in both preclinical
and clinical studies. The Pharmacology Shared Resource (PharmSR) provides a mechanism by which University
of Colorado Cancer Center (UCCC) investigators can plan and carry out pharmacokinetic (PK) and
pharmacodynamic (PD) studies in consultation with expert investigators. Equipment: Quantitative analytical
methods offered include high performance liquid chromatography (HPLC) with UV/Vis and fluorescent detection,
LC tandem mass spectrometry (LC/MS/MS), and other biochemical analysis methods (e.g. ELISA, enzymatic).
Institutional support led to the purchase of an AB SCIEX QTRAP 6500 LC/MS/MS system during the last
funding period, providing state of the art technology to UCCC investigators. Services: Services offered by the
PharmSR include: (1) consultation on PK study design; (2) development, validation and implementation of
appropriate analytical assays for drugs in biological fluids and tissues; and (3) PK and PD modeling and
mathematical analysis of analytical data. PK modeling services include systems based approaches (non-
compartmental modeling), compartmental modeling, Physiologically-Based PK analyses (PBPK) and population
approaches. Consultation and Education: The PharmSR provides consultation to help members with limited
pharmacology or PK background to design appropriate experiments and analyze PK data. Consultations
provided to members roughly equates to approximately 5 letters of support being requested annually for grant
submission proposing use of the PharmSR. Management: The PharmSR is located at CSU and is an institutional
core jointly managed by the UCCC and CSU. CCSG funding represents 24% of the annual operating budget.
The remaining support comes from the CCTSI grant (13%) and user fees (63%). PharmSR is overseen by the
Associate Director of Translational Research. Use of Services: Since July 2011, 55 investigators have used the
PharmSR services. Thirty-six percent (20) were UCCC members representing four of the six UCCC programs
and generating 20 peer-reviewed publications. Future Directions: The Pharm SR is currently establishing
multiplex assays to directly quantitate panels of ATP-binding cassette (ABC) transporter proteins and drug
metabolizing enzymes (P450s) from in vitro, preclinical and patient specimens. The goal is for the PharmSR to
offer these focused proteomic assays to quantitate proteins relevant to drug development and mechanism of
action.

## Key facts

- **NIH application ID:** 10133541
- **Project number:** 5P30CA046934-33
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** Dan Theodorescu
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $119,227
- **Award type:** 5
- **Project period:** 1997-04-04 → 2022-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10133541

## Citation

> US National Institutes of Health, RePORTER application 10133541, Pharmacology Shared Resource (5P30CA046934-33). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10133541. Licensed CC0.

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