# Cancer Cell Biology Program

> **NIH NIH P30** · UNIVERSITY OF COLORADO DENVER · 2021 · $68,807

## Abstract

CANCER CELL BIOLOGY PROGRAM (Project-113)
ABSTRACT
Overview and Goals: Accumulation of defects in the regulation of cell behavior results in uncontrolled
proliferation, immune evasion, invasiveness and metastasis. Understanding these mechanisms will provide new
diagnostic markers and therapeutic targets. The major goal of the Cancer Cell Biology (CCB) Program is to foster
and improve research focused on dissecting the cellular regulatory functions that establish and maintain this
malignant phenotype and to apply this knowledge to translational and clinical investigations. CCB members have
expertise in many areas and disciplines: Cell Cycle Regulation, Apoptosis and Autophagy, Developmental
Biology and Stem Cells, Immunotherapy/Immunology, Signal Transduction and Tumor Microenvironment and
Metastasis. This deep and diverse expertise results in collaborations, enhanced training and facilitation of
technological innovations through UCCC Shared Resources (SR). Research Highlight: A multidisciplinary team
including members at the UCB consortium site mapped the cell cycle phosphoproteome of the yeast centrosome.
This molecular resource will provide foundational knowledge about the cell cycle in cancer and other diseases
(Science, 20111). Program Activities: To accomplish its goal, the CCB program co-leaders employ resources
provided by the UCCC to foster interactions by organizing retreats, mentoring programs, and weekly seminars
attended by program members, students, fellows, and non-program faculty. Our collaborative publications and
grants demonstrate the success of our endeavors. Furthermore, key members of the CCB Program have
collaborated effectively with other programs, resulting in joint grant awards and submissions. Members: The
program has 43 Full members with $2.2M in grant funding from NCI and $5.9M in other peer-reviewed research
grant funding in 2015. Members are from 5 basic science (21%) and 7 clinical (51%) departments in the SOM,
from the School of Dental Medicine (5%), and the School of Public Health (1%) at AMC; and the College of
Liberal Arts and Sciences (2%) at the downtown campus. Thirteen percent of members are at UCB; 2% at CSU;
and 5% are at non-consortium institutions. Program members published 690 cancer-relevant publications in the
previous grant period of which 41% were inter- and 17% were intra-programmatic. Future Directions: We will
enhance our high degree of productivity and collaborative science by continuing to support fundamental research
in cell biology, by guiding these fundamental discoveries into the clinic and by leveraging the scientific strengths
found in the consortium institutions unique to the State of Colorado. Specifically, we will accomplish this goal by
enhancing the training and mentoring of students, fellows and junior faculty, by increasing the number of novel
cancer biology and mechanism discoveries that lead to collaborative scientific studies and are translated into
clinical applications, and by...

## Key facts

- **NIH application ID:** 10133557
- **Project number:** 5P30CA046934-33
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** Dan Theodorescu
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $68,807
- **Award type:** 5
- **Project period:** 1997-04-04 → 2022-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10133557

## Citation

> US National Institutes of Health, RePORTER application 10133557, Cancer Cell Biology Program (5P30CA046934-33). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10133557. Licensed CC0.

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