# The impact of natural selection and population structure on human genomic variation

> **NIH NIH R35** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2021 · $374,770

## Abstract

Project Summary
A key goal of evolutionary biology and human genetics is to understand the ways in
which natural selection has shaped genetic and phenotypic variation within and among
populations. The vast amount of population-genomic data, ancient DNA sequence data,
and genotype-phenotype mapping data being generated bring an unprecedented power
to address long-standing questions about the impact of adaptation in human evolution
and the role of migration and selection in driving genome-wide evolutionary change.
Our lab brings new tools from the intersection of population genetics and statistics to
address these questions, capitalizing on a range of new approaches, from building
genomic predictions of traits to the construction of genome-wide evolutionary
genealogies. To maximize the potential of these new data and approaches, we propose
to develop novel population-genomic models and statistical tools that address the roles
of natural selection and population structure in shaping population-genomic variation.
Specifically, the proposed work will: 1) Clarify how GWAS and population genetics can
be leveraged to both robustly identify signals of polygenic adaptation and problems with
confounding in GWAS; 2) Use genome-wide genealogies to estimate recent histories of
dispersal and selection; and 3) Estimate the proportion of allele-frequency change
driven by linked selection and the time scales over which selection acts, genome-wide.
The results of these projects will address fundamental questions about the structure of
human genomic variation.

## Key facts

- **NIH application ID:** 10133683
- **Project number:** 5R35GM136290-02
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** Graham Coop
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $374,770
- **Award type:** 5
- **Project period:** 2020-04-01 → 2025-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10133683

## Citation

> US National Institutes of Health, RePORTER application 10133683, The impact of natural selection and population structure on human genomic variation (5R35GM136290-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10133683. Licensed CC0.

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