# Cortical Bone Stem Cell Therapy for the Infarcted Heart

> **NIH NIH R01** · TEMPLE UNIV OF THE COMMONWEALTH · 2021 · $609,963

## Abstract

Project Summary:
Ischemic heart disease can lead to myocardial infarction (MI), a major cause of morbidity and
mortality worldwide. After MI scar forms in the affected region, the heart dilates, and cardiac function
is depressed and can lead to heart failure. Current therapies do not reverse or reduce the death of
tissue caused by MI. Cell therapy could be a new strategy to treat post MI remodeling, but to date has
been largely ineffective. We have recently identified a novel stem cell that resides deep within the
bone stroma, which we term Cortical Bone Stem Cells (CBSCs). We have shown, in a mouse MI
model, that CBSCs reduce scar size and enhance cardiac function after MI. These beneficial effects
appear to be mediated by paracrine mechanisms that we have shown can be cardioprotective,
angiogenic, and immune modulatory. The proposed research is the next step in determining if these
cells might be useful to treat patients who have suffered an MI. The Aims of this research are to
determine the best CBSC dose, route and time of delivery to induce more effective cardiac repair in a
swine MI model. We will also determine if CBSCs improve post MI remodeling by cardioprotective,
angiogenic, cardiogenic and/or immune modulatory effects. Our proposed study should provide novel
insights into how to use cell therapy to improve cardiac structure and function after MI.

## Key facts

- **NIH application ID:** 10133719
- **Project number:** 5R01HL139960-04
- **Recipient organization:** TEMPLE UNIV OF THE COMMONWEALTH
- **Principal Investigator:** Steven R Houser
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $609,963
- **Award type:** 5
- **Project period:** 2018-06-01 → 2023-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10133719

## Citation

> US National Institutes of Health, RePORTER application 10133719, Cortical Bone Stem Cell Therapy for the Infarcted Heart (5R01HL139960-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10133719. Licensed CC0.

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