# Core C - Mass Spectrometry

> **NIH NIH P01** · UNIVERSITY OF WASHINGTON · 2021 · $240,574

## Abstract

CORE C: MASS SPECTROMETRY – PROJECT SUMMARY/ABSTRACT
This Core will provide state of the art proteomics technologies and expertise to improve the understanding of
the molecular changes in the mitochondria associated with aging and reversal of aging by SS peptides. The
three research projects seek to understand the role of mitochondrial protective interventions on health and
lifespan in mouse and rat models. Integral to the success of the program project grant is the measurement of
changes in relative mitochondrial protein abundance and half-life in health, disease, and aging. To support the
needs of the individual research projects, the Proteomics Core has three aims, each of which provides services
in am important MS based technology: 1) The unbiased detection of differences in peptide/protein abundance
between complex mixtures; 2) The targeted analysis of protein abundance for mitochondrial proteins of
interest; 3) The global measurement of individual mitochondrial protein half-life; 4) Shotgun lipidomics of
cardiolipin molecular species.
These approaches span a range of broad and specific services that are tailored to optimal application by the
Program Project investigators.

## Key facts

- **NIH application ID:** 10134176
- **Project number:** 5P01AG001751-37
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** Michael MacCoss
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $240,574
- **Award type:** 5
- **Project period:** 1997-08-15 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10134176

## Citation

> US National Institutes of Health, RePORTER application 10134176, Core C - Mass Spectrometry (5P01AG001751-37). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10134176. Licensed CC0.

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