# Exposure Signatures Facility Core (ESFC)

> **NIH NIH P30** · WAYNE STATE UNIVERSITY · 2021 · $242,846

## Abstract

The Exposure Signatures Facility Core (ESFC) consists of six analytical resources that
contribute unique capabilities to identifying and quantifying toxicants and biological
responses to toxicant exposure. High performance omics technologies including
epigenomic, transcriptomic, and proteomic analyses are most frequently requested by
CURES Center investigators and form the base for the services offered by the ESFC.
With Center investigators increasingly focused on questions regarding the interaction of
environmental exposure and the physiological response to chemical and non-chemical
stressors we have added analytical resources for protein and DNA adducts, small
molecule toxicants and metabolites, cellular profiling, cytokines and lipids. Our
combined facilities include some of the most advanced analytical capabilities available
for targeted and untargeted analysis of the exposome and identification of exposure
signatures. Although we focus on the common matrices of blood, plasma and urine, we
can work with any biological or environmental sample matrix. Because few investigators
are completely familiar with the full scope and power of the services and technologies
available through the ESFC, we are available to consult with investigators when they
are planning a project. At that time, we offer advice regarding analytical end points they
might want to consider, how those end points could be achieved experimentally, and the
cost involved in doing that work. Such participation in the design of the project is
indispensable, as investigators are rarely familiar with which technology is most
appropriate for the study. The ESFC continues to work with investigators once data are
obtained. Omics technologies produce data sets that require specialized software
available in the laboratory where the data are generated. Using our experience with
bioinformatics interpretation of the data sets is the final step offered by the ESFC. The
complete ESFC package provides investigators with planning, advanced analytical
technology, expert technical assistance and informatics for interpretation of the results.

## Key facts

- **NIH application ID:** 10134343
- **Project number:** 5P30ES020957-08
- **Recipient organization:** WAYNE STATE UNIVERSITY
- **Principal Investigator:** Douglas M Ruden
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $242,846
- **Award type:** 5
- **Project period:** 2014-06-05 → 2024-06-19

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10134343

## Citation

> US National Institutes of Health, RePORTER application 10134343, Exposure Signatures Facility Core (ESFC) (5P30ES020957-08). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10134343. Licensed CC0.

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