Engaging stakeholders throughout the full spectrum of the research process leads to better science and, ultimately, better health outcomes. Yet, the 2014 National Center for Advancing Translational Science (NCATS) Advisory Council Working Group Report found 1) a paucity of community-driven research; and 2) that CTSA hubs lack sufficient infrastructure to support the science of community engagement. The Community Engagement Core (CEC) includes a portfolio of innovative programs and collaborations that demonstrate the benefits of engaging communities as active partners in research to addresses health priorities. We have worked to build capacity in the community-engaged research workforce via training, networking, and grants. Finally, the CEC has consulted with investigators and community stakeholders to optimize research processes and worked with other CCTST Cores and CTSA hubs to facilitate dissemination and implementation of best practices. In the Life Sciences, over 90% of published research is by two or more authors (1). The complexity of the problems studied requires integration of knowledge from many disciplines and the ability to develop and maintain effective teams. The siloed nature of universities and research institutions is partly responsible for challenges investigators face when trying to find collaborators from other disciplines. Our Center for Improvement Science (CIS) has taken a leadership role in developing mechanisms to build broad networks across disciplines, colleges, institutions, and the community. Our initial cross-disciplinary network has resulted in over $6 million in funding for interprofessional research and practice improvement projects. The CIS has also implemented a multi-level team science training program that includes basic to advanced workshops, a graduate-level course on Collaboration and Team Science, and Grand Rounds. In addition, we provide consultations for creating teams, improving teams and writing team-based grants. Finally, our expertise in quality improvement has built bridges between academic and health care systems to form a Learning Health Care System. We will build on our successful track record in community engagement and team science to: Aim 1: Further infuse community engagement within the CCTST and across the translational spectrum; Aim 2: Increase capacity for bi-directional engagement through expansion of educational offerings in community engagement and team science in translational research; Aim 3: Facilitate the development of multidisciplinary Learning Communities (LCs) that support the dissemination and implementation of best practices in community engagement and team science; and Aim 4: Implement an innovative team science program to enhance the effectiveness of multidisciplinary research teams.