# Project 1: Clonal Dynamics Guiding Curative Therapies for Acute Myeloid Leukemia

> **NIH NIH U54** · DANA-FARBER CANCER INST · 2020 · $126,492

## Abstract

Project Summary / Abstract 
Acute myeloid leukemia (AML) is rapidly fatal, poorly controlled disease that can be rapidly brought into 
complete remission but where relapse kills the vast majority of patients. The genetic evolution of the disease 
has been defined retrospectively, but the basis for resistance to therapy and effective strategies to overcome it 
are lacking. This project seeks to take advantage of well-defined mouse models where a human leukemogenic 
allele induces highly penetrant, lethal AML that can be temporarily brought into remission by chemotherapy 
agents used in patients. Combining these basic biologic features with novel strategies for quantitatively 
assessing clonal behavior, clonal molecular features, physical localization and the in vivo parameters of growth 
pathway, cell cycle and apoptosis over time will provide multidimensional datasets for mathematical modeling 
of the parameters correlating with: 1. Clonal dominance in vivo (Specific Aim 1) and, 2. Sensitivity/resistance to 
chemotherapy in vivo (Specific Aim 2). The models will guide experimental testing of the role of the 
parameters in the in vivo behavior of the disease that will then be used to develop and test methods for 
enhancing durable control of AML (Specific Aim 3).

## Key facts

- **NIH application ID:** 10134499
- **Project number:** 3U54CA193461-05S1
- **Recipient organization:** DANA-FARBER CANCER INST
- **Principal Investigator:** David T Scadden
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $126,492
- **Award type:** 3
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10134499

## Citation

> US National Institutes of Health, RePORTER application 10134499, Project 1: Clonal Dynamics Guiding Curative Therapies for Acute Myeloid Leukemia (3U54CA193461-05S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10134499. Licensed CC0.

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