# Pellegrini Administrative Supplements for Helium Recovery Systems

> **NIH NIH P20** · DARTMOUTH COLLEGE · 2020 · $231,950

## Abstract

Abstract
 Investments in biomedical research have paid large dividends in the form of groundbreaking
treatments for a host of diseases. Efforts to accelerate such benefits often assume there is a linear
progression that begins with an understanding of basic biological principles, and then advances to
therapeutic development, evaluation, and ultimately clinical application. As a result, many initiatives
focus on the stages that follow discovery. The Dartmouth Institute for Biomolecular Targeting
(iTarget) infuses even early-stage mechanistic investigation with a sophisticated awareness of
translational possibilities. This approach will ensure that knowledge of disease pathology provides
focus and context to enhance the impact of even the most fundamental research. At the same time, it
targets mechanistic investigations in directions that increase the probability of ultimate translational
success. iTarget is structured (1) to accelerate the research productivity and scientific impact of four
exceptional junior faculty members with interrelated interests in biomolecular target identification,
validation, and inhibition; (2) to provide a supportive framework for mentoring by experienced and
committed senior faculty; (3) to develop essential shared research resources not available at
Dartmouth or our regional IDeA partners and to facilitate access to existing cores; and (4) to recruit
new faculty to the Institute. With faculty engagement from 10 departments across the Faculty of Arts
and Sciences, Geisel School of Medicine, and Thayer School of Engineering, our initiative is truly
multidisciplinary. Dartmouth's collegial and highly interactive faculty have outstanding strength in
curiosity-based discovery, healthcare delivery and population-based outcomes analysis, and the
university has made key investments in translational research. iTarget will thus benefit from natural
research synergies that complement, but do not overlap with our programmatic partners. In return,
iTarget fills a critical role, bringing researchers together at the interface between basic and
translational sciences. It will thus stimulate interdisciplinary and innovative research projects to
address unmet therapeutic needs. It will also enhance the regional research infrastructure, providing
cutting-edge strategies for generating proteins and other molecular targeting tools and for visualizing
molecular interactions in purified systems and in cells. The He recovery system to be purchased with
the funds requested in this supplement, will ensure the long-term sustainability of the NMR facility,
one of the fundamental resources supported by iTarget, which enables cutting edge research by a
number of NIGMS funded faculty.

## Key facts

- **NIH application ID:** 10134610
- **Project number:** 3P20GM113132-05S1
- **Recipient organization:** DARTMOUTH COLLEGE
- **Principal Investigator:** DEAN R MADDEN
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $231,950
- **Award type:** 3
- **Project period:** 2016-05-15 → 2021-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10134610

## Citation

> US National Institutes of Health, RePORTER application 10134610, Pellegrini Administrative Supplements for Helium Recovery Systems (3P20GM113132-05S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10134610. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*