# Robust Rational Design of Chemical Tools to Inhibit RNA-binding Proteins

> **NIH NIH R01** · RESEARCH INST OF FOX CHASE CAN CTR · 2020 · $39,187

## Abstract

Project Summary
 This is a request for an NIGMS Administrative Supplement to NIGMS grant R01GM123336, to
purchase an ÄKTA Pure 25L chromatography system. The PI’s current chromatography system is heavily
utilized, and this represents the rate-limiting step for further progress in this already-successful project. We
currently rely on an older instrument that has been discontinued by the manufacturer and can no longer be
supported for repairs as needed. This is a joint request with another NIGMS-funded investigator, Dr. Jinhua
Wu, whose research group has also exceeded their chromatography capabilities and who also relies on a
nearly-identical older instrument. Access to the requested ÄKTA Pure 25L chromatography system will provide
the necessary capabilities to maximize productivity and fully achieve the aims of both NIGMS-sponsored
research projects. Institutional matching funds will contribute to the purchase of this instrument.

## Key facts

- **NIH application ID:** 10134704
- **Project number:** 3R01GM123336-03S1
- **Recipient organization:** RESEARCH INST OF FOX CHASE CAN CTR
- **Principal Investigator:** John Karanicolas
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $39,187
- **Award type:** 3
- **Project period:** 2017-09-30 → 2021-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10134704

## Citation

> US National Institutes of Health, RePORTER application 10134704, Robust Rational Design of Chemical Tools to Inhibit RNA-binding Proteins (3R01GM123336-03S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10134704. Licensed CC0.

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